OR8G5

Protein-coding gene in the species Homo sapiens
OR8G5
Identifiers
AliasesOR8G5, OR11-298, OR8G5P, OR8G6, olfactory receptor family 8 subfamily G member 5
External IDsMGI: 3030769; HomoloGene: 133683; GeneCards: OR8G5; OMA:OR8G5 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR8G5
Genomic location for OR8G5
Band11q24.2Start124,256,376 bp[1]
End124,266,224 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for OR8G5
Genomic location for OR8G5
Band9|9 A5.1Start38,905,267 bp[2]
End38,910,979 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • testicle

  • left testis

  • right testis

  • placenta

  • duodenum

  • transverse colon

  • urinary bladder

  • upper lobe of left lung

  • subcutaneous adipose tissue
Top expressed in
  • blastocyst
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • odorant binding
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

219865

258741

Ensembl

ENSG00000255298

ENSMUSG00000059595

UniProt

Q8NG78

Q8VG16

RefSeq (mRNA)

NM_001005198

NM_146746

RefSeq (protein)

NP_001005198

NP_666957

Location (UCSC)Chr 11: 124.26 – 124.27 MbChr 9: 38.91 – 38.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 8G5 is a protein that in humans is encoded by the OR8G5 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000255298 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059595 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR8G5 olfactory receptor, family 8, subfamily G, member 5".

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
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