OR4F4

Protein-coding gene in the species Homo sapiens
OR4F4
Identifiers
AliasesOR4F4, OLA-7501, OR4F18, olfactory receptor family 4 subfamily F member 4
External IDsMGI: 3031123; HomoloGene: 128250; GeneCards: OR4F4; OMA:OR4F4 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for OR4F4
Genomic location for OR4F4
Band15q26.3Start101,922,042 bp[1]
End101,923,113 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for OR4F4
Genomic location for OR4F4
Band2|2 E3Start111,311,164 bp[2]
End111,314,960 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • fundus

  • blood

  • muscle of leg

  • heart

  • esophagus

  • adrenal gland
Top expressed in
  • embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • transmembrane signaling receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • detection of chemical stimulus involved in sensory perception
  • signal transduction
  • response to stimulus
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26682

258399

Ensembl

ENSG00000177693

ENSMUSG00000061195

UniProt

Q96R69

Q8VF49

RefSeq (mRNA)

NM_001004195

NM_146404

RefSeq (protein)

NP_001004195

NP_666516

Location (UCSC)Chr 15: 101.92 – 101.92 MbChr 2: 111.31 – 111.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 4F4 is a protein that in humans is encoded by the OR4F4 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177693 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061195 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR4F4 olfactory receptor, family 4, subfamily F, member 4".

Further reading

  • Trask BJ, Friedman C, Martin-Gallardo A, et al. (1998). "Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes". Hum. Mol. Genet. 7 (1): 13–26. doi:10.1093/hmg/7.1.13. PMID 9384599.
  • Mefford HC, Linardopoulou E, Coil D, et al. (2002). "Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes". Hum. Mol. Genet. 10 (21): 2363–72. doi:10.1093/hmg/10.21.2363. PMID 11689483.
  • Linardopoulou E, Mefford HC, Nguyen O, et al. (2002). "Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location". Hum. Mol. Genet. 10 (21): 2373–83. doi:10.1093/hmg/10.21.2373. PMID 11689484.
  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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