OR11H6

Protein-coding gene in the species Homo sapiens
OR11H6
Identifiers
AliasesOR11H6, olfactory receptor family 11 subfamily H member 6
External IDsMGI: 3030579; HomoloGene: 27116; GeneCards: OR11H6; OMA:OR11H6 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for OR11H6
Genomic location for OR11H6
Band14q11.2Start20,223,710 bp[1]
End20,224,702 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for OR11H6
Genomic location for OR11H6
Band14|14 C1Start50,876,845 bp[2]
End50,881,342 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • right auricle
Top expressed in
  • respiratory epithelium

  • nasal epithelium

  • olfactory epithelium

  • proximal tubule

  • olfactory bulb

  • lung
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • olfactory receptor activity
  • signal transducer activity
  • G protein-coupled receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • signal transduction
  • response to stimulus
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

122748

258296

Ensembl

ENSG00000176219

ENSMUSG00000050028

UniProt

Q8NGC7

Q7TRL9

RefSeq (mRNA)

NM_001004480

NM_146299

RefSeq (protein)

NP_001004480

NP_666411

Location (UCSC)Chr 14: 20.22 – 20.22 MbChr 14: 50.88 – 50.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 11H6 is a protein that in humans is encoded by the OR11H6 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176219 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050028 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR11H6 olfactory receptor, family 11, subfamily H, member 6".
  6. ^ Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D (October 2007). "Genetic elucidation of human hyperosmia to isovaleric acid". PLOS Biology. 5 (11): e284. doi:10.1371/journal.pbio.0050284. PMC 2043052. PMID 17973576.

Further reading

  • Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
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Family 13
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