Protein-coding gene in the species Homo sapiens
| OR4A15 |
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| Identifiers |
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| Aliases | OR4A15, OR11-118, olfactory receptor family 4 subfamily A member 15 |
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| External IDs | MGI: 3031068; HomoloGene: 128156; GeneCards: OR4A15; OMA:OR4A15 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 11 (human)[1] |
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| | Band | 11q11 | Start | 55,367,974 bp[1] |
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| End | 55,368,918 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 2 (mouse)[2] |
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| | Band | 2|2 E1 | Start | 89,190,357 bp[2] |
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| End | 89,195,209 bp[2] |
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| Gene ontology |
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| Molecular function | - G protein-coupled receptor activity
- olfactory receptor activity
- transmembrane signaling receptor activity
- signal transducer activity
| | Cellular component | - integral component of membrane
- plasma membrane
- membrane
| | Biological process | - sensory perception of smell
- detection of chemical stimulus involved in sensory perception of smell
- detection of chemical stimulus involved in sensory perception
- signal transduction
- response to stimulus
- G protein-coupled receptor signaling pathway
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 11: 55.37 – 55.37 Mb | Chr 2: 89.19 – 89.2 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Olfactory receptor 4A15 is a protein that in humans is encoded by the OR4A15 gene.[5]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000181958 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075090 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR4A15 olfactory receptor, family 4, subfamily A, member 15".
Further reading
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class I
(fish-like receptors) | | Family 51 | |
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| Family 56 | |
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Class II
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