OR56B1

Protein-coding gene in the species Homo sapiens
OR56B1
Identifiers
AliasesOR56B1, OR11-65, OR56B1P, olfactory receptor family 56 subfamily B member 1
External IDsMGI: 3030338; HomoloGene: 17189; GeneCards: OR56B1; OMA:OR56B1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR56B1
Genomic location for OR56B1
Band11p15.4Start5,736,448 bp[1]
End5,738,523 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for OR56B1
Genomic location for OR56B1
Band7|7 E3Start108,164,043 bp[2]
End108,165,000 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • appendix

  • lymph node

  • spleen

  • Descending thoracic aorta

  • tibial nerve

  • canal of the cervix

  • gallbladder

  • intestinal epithelium

  • ectocervix
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • olfactory receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • response to stimulus
  • signal transduction
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

387748

258163

Ensembl

ENSG00000181023

ENSMUSG00000060105

UniProt

Q8NGI3

Q7TRU7

RefSeq (mRNA)

NM_001005180

NM_001011858

RefSeq (protein)

NP_001005180

NP_001011858

Location (UCSC)Chr 11: 5.74 – 5.74 MbChr 7: 108.16 – 108.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 56B1 is a protein that in humans is encoded by the OR56B1 gene.[5]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181023 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060105 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR56B1 olfactory receptor, family 56, subfamily B, member 1".

Further reading

  • Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
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