OR2T2

Protein-coding gene in the species Homo sapiens
OR2T2
Identifiers
AliasesOR2T2, OR1-43, OR2T2P, olfactory receptor family 2 subfamily T member 2
External IDsHomoloGene: 66506; GeneCards: OR2T2; OMA:OR2T2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for OR2T2
Genomic location for OR2T2
Band1q44Start248,445,512 bp[1]
End248,455,725 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • human kidney

  • ventricular zone

  • renal cortex

  • skin of abdomen

  • left ventricle
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

401992

n/a

Ensembl

ENSG00000275754
ENSG00000196240
ENSG00000276821

n/a

UniProt

Q6IF00

n/a

RefSeq (mRNA)

NM_001004136

n/a

RefSeq (protein)

NP_001004136

n/a

Location (UCSC)Chr 1: 248.45 – 248.46 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Olfactory receptor 2T2 is a protein that in humans is encoded by the OR2T2 gene.[3][4]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

See also

References

  1. ^ a b c ENSG00000196240, ENSG00000276821 GRCh38: Ensembl release 89: ENSG00000275754, ENSG00000196240, ENSG00000276821 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Malnic B, Godfrey PA, Buck LB (Feb 2004). "The human olfactory receptor gene family". Proc Natl Acad Sci U S A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  4. ^ a b "Entrez Gene: OR2T2 olfactory receptor, family 2, subfamily T, member 2".

Further reading

  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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