Protein-coding gene in the species Homo sapiens
OR2T2 |
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Identifiers |
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Aliases | OR2T2, OR1-43, OR2T2P, olfactory receptor family 2 subfamily T member 2 |
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External IDs | HomoloGene: 66506; GeneCards: OR2T2; OMA:OR2T2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 1 (human)[1] |
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| Band | 1q44 | Start | 248,445,512 bp[1] |
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End | 248,455,725 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - human kidney
- ventricular zone
- renal cortex
- skin of abdomen
- left ventricle
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| | More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - G protein-coupled receptor activity
- olfactory receptor activity
- signal transducer activity
| Cellular component | - integral component of membrane
- plasma membrane
- membrane
| Biological process | - sensory perception of smell
- signal transduction
- response to stimulus
- detection of chemical stimulus involved in sensory perception of smell
- G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000275754 ENSG00000196240 ENSG00000276821 |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 248.45 – 248.46 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Olfactory receptor 2T2 is a protein that in humans is encoded by the OR2T2 gene.[3][4]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]
See also
References
- ^ a b c ENSG00000196240, ENSG00000276821 GRCh38: Ensembl release 89: ENSG00000275754, ENSG00000196240, ENSG00000276821 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Malnic B, Godfrey PA, Buck LB (Feb 2004). "The human olfactory receptor gene family". Proc Natl Acad Sci U S A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
- ^ a b "Entrez Gene: OR2T2 olfactory receptor, family 2, subfamily T, member 2".
Further reading
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class I (fish-like receptors) | Family 51 | |
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Family 52 | |
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Family 56 | |
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Class II (tetrapod specific receptors) | Family 1 | |
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Family 13 | |
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