OR5A1

Protein-coding gene in the species Homo sapiens
OR5A1
Identifiers
AliasesOR5A1, OR11-249, OR5A1P, OST181, olfactory receptor family 5 subfamily A member 1
External IDsMGI: 2153205; HomoloGene: 17342; GeneCards: OR5A1; OMA:OR5A1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR5A1
Genomic location for OR5A1
Band11q12.1Start59,436,469 bp[1]
End59,451,380 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for OR5A1
Genomic location for OR5A1
Band19|19 AStart12,095,360 bp[2]
End12,100,567 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle
Top expressed in
  • respiratory epithelium

  • nasal epithelium

  • peripheral nervous system

  • olfactory epithelium

  • embryo

  • blastocyst
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • odorant binding
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

219982

258677

Ensembl

ENSG00000172320

ENSMUSG00000067522

UniProt

Q8NGJ0

Q8VFV2

RefSeq (mRNA)

NM_001004728

NM_146682

RefSeq (protein)

NP_001004728

NP_666893

Location (UCSC)Chr 11: 59.44 – 59.45 MbChr 19: 12.1 – 12.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 5A1 is a protein that in humans is encoded by the OR5A1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Genetic differences

A single-nucleotide polymorphism in the OR5A1 receptor (rs6591536[6]) causes very significant differences in the odor perception of beta-ionone, both in sensitivity and also in subjective quality. Individuals who contain at least one G allele are sensitive to beta-ionone and perceive a pleasant floral scent, while individuals who are homozygous AA are ~100 times less sensitive and at higher concentrations perceive a pungent sour/vinegar odor instead.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172320 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067522 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR5A1 olfactory receptor, family 5, subfamily A, member 1".
  6. ^ "rs6591536". SNPedia.
  7. ^ Jaeger SR, McRae JF, Bava CM, Beresford MK, Hunter D, Jia Y, Chheang SL, Jin D, Peng M, Gamble JC, Atkinson KR, Axten LG, Paisley AG, Tooman L, Pineau B, Rouse SA, Newcomb RD (2013). "A Mendelian Trait for Olfactory Sensitivity Affects Odor Experience and Food Selection". Current Biology. 23 (16): 1601–1605. Bibcode:2013CBio...23.1601J. doi:10.1016/j.cub.2013.07.030. PMID 23910657.

Further reading

  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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