Protein-coding gene in the species Homo sapiens
OR5A1 |
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Identifiers |
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Aliases | OR5A1, OR11-249, OR5A1P, OST181, olfactory receptor family 5 subfamily A member 1 |
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External IDs | MGI: 2153205; HomoloGene: 17342; GeneCards: OR5A1; OMA:OR5A1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 11 (human)[1] |
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| Band | 11q12.1 | Start | 59,436,469 bp[1] |
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End | 59,451,380 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 19 (mouse)[2] |
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| Band | 19|19 A | Start | 12,095,360 bp[2] |
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End | 12,100,567 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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| Top expressed in | - respiratory epithelium
- nasal epithelium
- peripheral nervous system
- olfactory epithelium
- embryo
- blastocyst
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - G protein-coupled receptor activity
- odorant binding
- olfactory receptor activity
- signal transducer activity
| Cellular component | - integral component of membrane
- plasma membrane
- membrane
| Biological process | - sensory perception of smell
- signal transduction
- response to stimulus
- detection of chemical stimulus involved in sensory perception of smell
- G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 11: 59.44 – 59.45 Mb | Chr 19: 12.1 – 12.1 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Olfactory receptor 5A1 is a protein that in humans is encoded by the OR5A1 gene.[5]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
Genetic differences
A single-nucleotide polymorphism in the OR5A1 receptor (rs6591536[6]) causes very significant differences in the odor perception of beta-ionone, both in sensitivity and also in subjective quality. Individuals who contain at least one G allele are sensitive to beta-ionone and perceive a pleasant floral scent, while individuals who are homozygous AA are ~100 times less sensitive and at higher concentrations perceive a pungent sour/vinegar odor instead.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000172320 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067522 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR5A1 olfactory receptor, family 5, subfamily A, member 1".
- ^ "rs6591536". SNPedia.
- ^ Jaeger SR, McRae JF, Bava CM, Beresford MK, Hunter D, Jia Y, Chheang SL, Jin D, Peng M, Gamble JC, Atkinson KR, Axten LG, Paisley AG, Tooman L, Pineau B, Rouse SA, Newcomb RD (2013). "A Mendelian Trait for Olfactory Sensitivity Affects Odor Experience and Food Selection". Current Biology. 23 (16): 1601–1605. Bibcode:2013CBio...23.1601J. doi:10.1016/j.cub.2013.07.030. PMID 23910657.
Further reading
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class I (fish-like receptors) | Family 51 | |
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Family 52 | |
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Family 56 | |
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Class II (tetrapod specific receptors) | Family 1 | |
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Family 11 | |
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