OR2H1

Protein-coding gene in the species Homo sapiens
OR2H1
Identifiers
AliasesOR2H1, 6M1-16, HS6M1-16, OLFR42A-9004-14, OR2H6, OR2H8, OR6-2, dJ994E9.4, OLFR42A-9004.14/9026.2, olfactory receptor family 2 subfamily H member 1
External IDsMGI: 2177474; HomoloGene: 72346; GeneCards: OR2H1; OMA:OR2H1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for OR2H1
Genomic location for OR2H1
Band6p22.1Start29,457,155 bp[1]
End29,464,328 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for OR2H1
Genomic location for OR2H1
Band17|17 B1Start37,401,510 bp[2]
End37,409,170 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • right testis

  • left testis

  • gallbladder

  • caudate nucleus

  • cell

  • monocyte

  • uterine tube

  • hypothalamus

  • blood
Top expressed in
  • limb bud
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26716

258470

Ensembl
ENSG00000206516
ENSG00000204688
ENSG00000224395
ENSG00000206471
ENSG00000229125

ENSG00000232984
ENSG00000229408
ENSG00000235132

ENSMUSG00000095377

UniProt

Q9GZK4

Q7TRL3

RefSeq (mRNA)

NM_030883
NM_001318014
NM_001318022

NM_182714

RefSeq (protein)

NP_001304943
NP_001304951
NP_112145

NP_874373

Location (UCSC)Chr 6: 29.46 – 29.46 MbChr 17: 37.4 – 37.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2H1 is a protein that in humans is encoded by the OR2H1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c ENSG00000204688, ENSG00000224395, ENSG00000206471, ENSG00000229125, ENSG00000232984, ENSG00000229408, ENSG00000235132 GRCh38: Ensembl release 89: ENSG00000206516, ENSG00000204688, ENSG00000224395, ENSG00000206471, ENSG00000229125, ENSG00000232984, ENSG00000229408, ENSG00000235132 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000095377 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR2H1 olfactory receptor, family 2, subfamily H, member 1".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Volz A, Ehlers A, Younger R, et al. (2003). "Complex transcription and splicing of odorant receptor genes". J. Biol. Chem. 278 (22): 19691–701. doi:10.1074/jbc.M212424200. PMID 12637542.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Santos PS, Kellermann T, Uchanska-Ziegler B, et al. (2010). "Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species". Immunogenetics. 62 (9): 569–84. doi:10.1007/s00251-010-0468-6. PMID 20680261. S2CID 23003444.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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