OR51B2

Protein-coding gene in the species Homo sapiens
OR51B2
Identifiers
AliasesOR51B2, HOR5'Beta3, OR51B1P, olfactory receptor family 51 subfamily B member 2 (gene/pseudogene), olfactory receptor family 51 subfamily B member 2
External IDsMGI: 1341900; HomoloGene: 56593; GeneCards: OR51B2; OMA:OR51B2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR51B2
Genomic location for OR51B2
Band11p15.4Start5,323,359 bp[1]
End5,324,297 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for OR51B2
Genomic location for OR51B2
Band7|7 E3Start103,538,692 bp[2]
End103,543,692 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibialis anterior muscle

  • pancreatic ductal cell

  • mucosa of ileum

  • deltoid muscle

  • skin of thigh

  • Achilles tendon

  • lower lobe of lung
Top expressed in
  • submandibular gland

  • sternocleidomastoid muscle

  • temporal muscle

  • tibialis anterior muscle

  • vastus lateralis muscle

  • median eminence
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79345

18366

Ensembl

ENSG00000279012

ENSMUSG00000063615

UniProt

Q9Y5P1

F8VPZ8

RefSeq (mRNA)

NM_033180

NM_013617

RefSeq (protein)

NP_149420

NP_038645

Location (UCSC)Chr 11: 5.32 – 5.32 MbChr 7: 103.54 – 103.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 51B2 is a protein that in humans is encoded by the OR51B2 gene.[5]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

As of 2015, OR51B2 was an orphan receptor, meaning that no odorants have been identified which bind to it.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000279012 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063615 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR51B2 olfactory receptor, family 51, subfamily B, member 2".
  6. ^ de March CA, Ryu S, Sicard G, Moon C, Golebiowski J (September 2015). "Structure–odour relationships reviewed in the postgenomic era". Flavour and Fragrance Journal. 30 (5): 342–361. doi:10.1002/ffj.3249.

Further reading

  • Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M, von Doorninck JH (April 1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 5129–34. Bibcode:1999PNAS...96.5129B. doi:10.1073/pnas.96.9.5129. PMC 21828. PMID 10220430.
  • Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R (December 2000). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14560–5. Bibcode:2000PNAS...9714560B. doi:10.1073/pnas.97.26.14560. PMC 18958. PMID 11121057.
  • Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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