ZNF202

Protein-coding gene in the species Homo sapiens
ZNF202
Identifiers
AliasesZNF202, ZKSCAN10, ZSCAN42, zinc finger protein 202
External IDsOMIM: 603430; MGI: 1933401; HomoloGene: 68317; GeneCards: ZNF202; OMA:ZNF202 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ZNF202
Genomic location for ZNF202
Band11q24.1Start123,723,914 bp[1]
End123,741,675 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for ZNF202
Genomic location for ZNF202
Band9|9 A5.1Start40,103,612 bp[2]
End40,124,900 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • body of pancreas

  • left uterine tube

  • rectum

  • ganglionic eminence

  • monocyte

  • right lobe of thyroid gland

  • gastrocnemius muscle

  • canal of the cervix

  • transverse colon
Top expressed in
  • spermatocyte

  • urethra

  • female urethra

  • male urethra

  • trigeminal ganglion

  • yolk sac

  • spermatid

  • renal corpuscle

  • substantia nigra

  • primitive streak
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nucleic acid binding
  • DNA-binding transcription factor activity
  • metal ion binding
  • DNA binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • intracellular anatomical structure
Biological process
  • lipid metabolism
  • transcription by RNA polymerase II
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7753

80902

Ensembl

ENSG00000166261

ENSMUSG00000025602

UniProt

O95125

n/a

RefSeq (mRNA)

NM_001301779
NM_001301780
NM_001301819
NM_003455

NM_030713
NM_001359464

RefSeq (protein)

NP_001288708
NP_001288709
NP_001288748
NP_003446

n/a

Location (UCSC)Chr 11: 123.72 – 123.74 MbChr 9: 40.1 – 40.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 202 is a transcription factor first associated with breast cancer. It is a protein that, in humans, is encoded by the ZNF202 gene.[5][6]

Clinical significance

Variants of this protein have been discovered to be strongly associated with coronary heart disease and atherosclerosis.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166261 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025602 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M (Sep 1998). "Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins". Genomics. 52 (3): 358–62. doi:10.1006/geno.1998.5419. PMID 9790754.
  6. ^ "Entrez Gene: ZNF202 zinc finger protein 202".

Further reading

  • Iuchi S, Kuldell N (2005). Zinc finger proteins: from atomic contact to cellular function. Molecular biology intelligence unit. シュプリンガー・ジャパン株式会社. p. 161. ISBN 0-306-48229-0.
  • Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. S2CID 21839750.
  • Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry. 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.
  • Wagner S, Hess MA, Ormonde-Hanson P, Malandro J, Hu H, Chen M, Kehrer R, Frodsham M, Schumacher C, Beluch M, Honer C, Skolnick M, Ballinger D, Bowen BR (May 2000). "A broad role for the zinc finger protein ZNF202 in human lipid metabolism". The Journal of Biological Chemistry. 275 (21): 15685–90. doi:10.1074/jbc.M910152199. PMID 10748193.
  • Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G (Apr 2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". The Journal of Biological Chemistry. 276 (15): 12427–33. doi:10.1074/jbc.M100218200. PMID 11279031.
  • Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal. 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A (Sep 2006). "Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study". Atherosclerosis. 188 (1): 43–50. doi:10.1016/j.atherosclerosis.2005.10.014. PMID 16289551.
  • Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A (May 2006). "Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population". Journal of Lipid Research. 47 (5): 944–52. doi:10.1194/jlr.M500521-JLR200. PMID 16467280.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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