ZBTB21

Protein-coding gene in the species Homo sapiens
ZBTB21
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

1WJP

Identifiers
AliasesZBTB21, ZNF295, zinc finger and BTB domain containing 21
External IDsOMIM: 616485; MGI: 1927240; HomoloGene: 10799; GeneCards: ZBTB21; OMA:ZBTB21 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for ZBTB21
Genomic location for ZBTB21
Band21q22.3Start41,986,831 bp[1]
End42,010,387 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for ZBTB21
Genomic location for ZBTB21
Band16|16 C4Start97,744,557 bp[2]
End97,763,822 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tail of epididymis

  • endothelial cell

  • pancreatic epithelial cell

  • corpus epididymis

  • secondary oocyte

  • caput epididymis

  • Brodmann area 23

  • cartilage tissue

  • mucosa of paranasal sinus

  • Achilles tendon
Top expressed in
  • lumbar spinal ganglion

  • zygote

  • secondary oocyte

  • primary oocyte

  • tail of embryo

  • yolk sac

  • Rostral migratory stream

  • Paneth cell

  • spermatocyte

  • otic vesicle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • methyl-CpG binding
  • DNA binding
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
  • cytosol
Biological process
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

49854

114565

Ensembl

ENSG00000173276

ENSMUSG00000046962

UniProt

Q9ULJ3

n/a

RefSeq (mRNA)

NM_001098402
NM_001098403
NM_020727
NM_001320729
NM_001320731

NM_001081684
NM_001081685
NM_175428
NM_001320385

RefSeq (protein)

NP_001091872
NP_001091873
NP_001307658
NP_001307660
NP_065778

n/a

Location (UCSC)Chr 21: 41.99 – 42.01 MbChr 16: 97.74 – 97.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger and BTB domain-containing protein 21 is a protein that in humans is encoded by the ZBTB21 gene.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173276 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046962 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ZNF295 zinc finger protein 295".

Further reading

  • Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
  • Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Wang J, Kudoh J, Takayanagi A, Shimizu N (Feb 2005). "Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161". Biochemical and Biophysical Research Communications. 327 (2): 615–27. doi:10.1016/j.bbrc.2004.12.048. PMID 15629158.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

  • v
  • t
  • e
  • 1wjp: Solution structure of zf-C2H2 domains from human Zinc finger protein 295
    1wjp: Solution structure of zf-C2H2 domains from human Zinc finger protein 295
  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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