ST8SIA4

ST8SIA4
Identifikatori
AlijasiST8SIA4
Spoljašnji IDOMIM: 602547 MGI: 106018 HomoloGene: 4147 GeneCards: ST8SIA4
Genska lokacija (miš)
Chromosome 1 (mouse)
Hr.Chromosome 1 (mouse)[1]
Chromosome 1 (mouse)
Genomska lokacija za ST8SIA4
Genomska lokacija za ST8SIA4
Band1|1 DStart95,587,682 bp[1]
Kraj95,667,571 bp[1]
Obrazac RNK izražavanja
More reference expression data
Genska ontologija
Molecular function• sialyltransferase activity
• sialic acid binding
• glycosyltransferase activity
• transferase activity
• alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
Cellular component• саставни део мембране
• Golgi membrane
• мембрана
• Голџијев апарат
Biological process• ментални развој
• GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation
• N-glycan processing
• ganglioside biosynthetic process
• oligosaccharide metabolic process
• sialylation
Sources:Amigo / QuickGO
Ortolozi
VrsteČovekMiš
Entrez

7903

20452

Ensembl

ENSG00000113532

ENSMUSG00000040710

UniProt

Q92187

Q64692

RefSeq (mRNA)

NM_005668
NM_175052

NM_001159745
NM_009183

RefSeq (protein)

NP_005659
NP_778222

NP_001153217
NP_033209

Location (UCSC)n/aChr 1: 95.59 – 95.67 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

CMP-N-acetilneuraminat-poli-alfa-2,8-sijaliltransferaza je enzim koji je kod ljudi kodiran genom ST8SIA4.[4][5]

Reference

  1. ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000040710 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Nakayama J, Fukuda MN, Fredette B, Ranscht B, Fukuda M (август 1995). „Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain”. Proc Natl Acad Sci U S A. 92 (15): 7031—5. Bibcode:1995PNAS...92.7031N. PMC 41465 Слободан приступ. PMID 7624364. doi:10.1073/pnas.92.15.7031 Слободан приступ. CS1 одржавање: Формат датума (веза)
  5. ^ „Entrez Gene: ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4”. 

Literatura

  • Cohn JA, Noone PG, Jowell PS (2002). „Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene”. J. Investig. Med. 50 (5): 247S—255S. PMID 12227654. S2CID 34017638. doi:10.1136/jim-50-suppl5-01. 
  • Eckhardt M; Mühlenhoff M; Bethe A; et al. (1995). „Molecular characterization of eukaryotic polysialyltransferase-1”. Nature. 373 (6516): 715—8. Bibcode:1995Natur.373..715E. PMID 7854457. S2CID 4345323. doi:10.1038/373715a0. 
  • Angata K; Nakayama J; Fredette B; et al. (1997). „Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST”. J. Biol. Chem. 272 (11): 7182—90. PMID 9054414. doi:10.1074/jbc.272.11.7182 Слободан приступ. 
  • Angata K, Suzuki M, Fukuda M (1998). „Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX”. J. Biol. Chem. 273 (43): 28524—32. PMID 9774483. doi:10.1074/jbc.273.43.28524. 
  • Close BE, Colley KJ (1999). „In vivo autopolysialylation and localization of the polysialyltransferases PST and STX”. J. Biol. Chem. 273 (51): 34586—93. PMID 9852130. doi:10.1074/jbc.273.51.34586 Слободан приступ. 
  • Close BE, Tao K, Colley KJ (2000). „Polysialyltransferase-1 autopolysialylation is not requisite for polysialylation of neural cell adhesion molecule”. J. Biol. Chem. 275 (6): 4484—91. PMID 10660622. doi:10.1074/jbc.275.6.4484 Слободан приступ. 
  • Angata K; Suzuki M; McAuliffe J; et al. (2000). „Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III”. J. Biol. Chem. 275 (24): 18594—601. PMID 10766765. doi:10.1074/jbc.M910204199 Слободан приступ. 
  • Angata K; Yen TY; El-Battari A; et al. (2001). „Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity”. J. Biol. Chem. 276 (18): 15369—77. PMID 11279095. doi:10.1074/jbc.M100576200 Слободан приступ. 
  • Close BE; Wilkinson JM; Bohrer TJ; et al. (2002). „The polysialyltransferase ST8Sia II/STX: posttranslational processing and role of autopolysialylation in the polysialylation of neural cell adhesion molecule”. Glycobiology. 11 (11): 997—1008. PMID 11744634. doi:10.1093/glycob/11.11.997 Слободан приступ. 
  • Nałogowska-Głośnicka K; Łacka B; Zychma M; et al. (2002). „[Relationship between SA gene Pst1 polymorphism and predisposition to H-gestosis]”. Pol. Arch. Med. Wewn. 107 (1): 7—11. PMID 12046348. 
  • Angata K, Suzuki M, Fukuda M (2002). „ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes”. J. Biol. Chem. 277 (39): 36808—17. PMID 12138100. doi:10.1074/jbc.M204632200 Слободан приступ. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899 Слободан приступ. 
  • Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 Слободан приступ. PMID 15489334. doi:10.1101/gr.2596504. 
  • Beecken WD; Engl T; Ogbomo H; et al. (2005). „Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells”. Int. Immunopharmacol. 5 (4): 757—69. PMID 15710344. doi:10.1016/j.intimp.2004.12.009. 
  • Mendiratta SS, Sekulic N, Lavie A, Colley KJ (2005). „Specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule play a role in its recognition and polysialylation by the polysialyltransferase ST8Sia IV/PST”. J. Biol. Chem. 280 (37): 32340—8. PMID 16027151. doi:10.1074/jbc.M506217200 Слободан приступ. 
  • Wang B, Hu H, Yu B (2007). „Molecular characterization of pig ST8Sia IV--a critical gene for the formation of neural cell adhesion molecule and its response to sialic acid supplement in piglets”. Nutritional Neuroscience. 9 (3–4): 147—54. PMID 17176637. S2CID 7793568. doi:10.1080/10284150600903594. 
  • Szabo R, Skropeta D, et al. (2017). „Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities.”. Med. Res. Rev. 37 (2): 210—270. PMID 27678392. S2CID 26280291. doi:10.1002/med.21407. 
  • п
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2.4.1: Heksozil-
transferaze
Glukozil-
Galaktozil-
Glukuronozil-
Fukozil-
Manozil-
2.4.2: Pentozil-
transferaze
Riboza
ADP-riboziltransferaza
Fosforiboziltransferaza
Drugi
Drugi
2.4.99: Sijalil
transferaze
  • п
  • р
  • у
Teme
Tipovi
  • B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6