HAS3

HAS3
Identifikatori
AlijasiHAS3
Spoljašnji IDOMIM: 602428 MGI: 109599 HomoloGene: 68461 GeneCards: HAS3
Genska lokacija (miš)
Chromosome 8 (mouse)
Hr.Chromosome 8 (mouse)[1]
Chromosome 8 (mouse)
Genomska lokacija za HAS3
Genomska lokacija za HAS3
Band8 D3|8 53.28 cMStart107,596,874 bp[1]
Kraj107,611,198 bp[1]
Genska ontologija
Molecular function• transferase activity
• glycosyltransferase activity
• hyaluronan synthase activity
• GO:0001948, GO:0016582 везивање за протеине плазме
• identical protein binding
Cellular component• цитоплазма
• саставни део мембране
• ћелијска мембрана
• hyaluranon cable
• integral component of plasma membrane
• мембрана
Biological process• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• Ćelijska adhezija
• hyaluronan biosynthetic process
• extracellular matrix assembly
• positive regulation of hyaluranon cable assembly
• extracellular polysaccharide biosynthetic process
• Метаболизам угљених хидрата
Sources:Amigo / QuickGO
Ortolozi
VrsteČovekMiš
Entrez

3038

15118

Ensembl

ENSG00000103044

ENSMUSG00000031910

UniProt

O00219

O08650

RefSeq (mRNA)

NM_001199280
NM_005329
NM_138612

NM_008217
NM_001331048

RefSeq (protein)

NP_001186209
NP_005320
NP_619515

NP_001317977
NP_032243

Location (UCSC)n/aChr 8: 107.6 – 107.61 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Hijaluronanska sintaza 3 je enzim koji je kod ljudi kodiran genom HAS3.[4][5][6]

Reference

  1. ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000031910 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (јул 1997). „Chromosomal localization of the human and mouse hyaluronan synthase genes”. Genomics. 41 (3): 493—7. PMID 9169154. doi:10.1006/geno.1997.4696. CS1 одржавање: Формат датума (веза)
  5. ^ Spicer AP, Olson JS, McDonald JA (мај 1997). „Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase”. J Biol Chem. 272 (14): 8957—61. PMID 9083017. doi:10.1074/jbc.272.14.8957 Слободан приступ. CS1 одржавање: Формат датума (веза)
  6. ^ „Entrez Gene: HAS3 hyaluronan synthase 3”. 

Literatura

  • Jacobson A, Brinck J, Briskin MJ, et al. (2000). „Expression of human hyaluronan synthases in response to external stimuli.”. Biochem. J. 348. Pt 1 (1): 29—35. PMC 1221032 Слободан приступ. PMID 10794710. doi:10.1042/0264-6021:3480029. 
  • Simpson MA, Reiland J, Burger SR, et al. (2001). „Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells.”. J. Biol. Chem. 276 (21): 17949—57. PMID 11278609. doi:10.1074/jbc.M010064200 Слободан приступ. 
  • Kuroda K, Utani A, Hamasaki Y, Shinkai H (2001). „Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts.”. J. Dermatol. Sci. 26 (2): 156—60. PMID 11378333. doi:10.1016/S0923-1811(00)00155-9. 
  • Liu N, Gao F, Han Z, et al. (2001). „Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.”. Cancer Res. 61 (13): 5207—14. PMID 11431361. 
  • Simpson MA, Wilson CM, Furcht LT, et al. (2002). „Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells.”. J. Biol. Chem. 277 (12): 10050—7. PMID 11790779. doi:10.1074/jbc.M110069200 Слободан приступ. 
  • Sayo T, Sugiyama Y, Takahashi Y, et al. (2002). „Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes.”. J. Invest. Dermatol. 118 (1): 43—8. PMID 11851874. doi:10.1046/j.0022-202x.2001.01613.x Слободан приступ. 
  • Chagnon P, Michaud J, Mitchell G, et al. (2003). „A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.”. Am. J. Hum. Genet. 71 (6): 1443—9. PMC 378590 Слободан приступ. PMID 12417987. doi:10.1086/344580. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899 Слободан приступ. 
  • Bullard KM, Kim HR, Wheeler MA, et al. (2004). „Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth.”. Int. J. Cancer. 107 (5): 739—46. PMID 14566823. S2CID 24405794. doi:10.1002/ijc.11475 Слободан приступ. 
  • Suzuki K, Yamamoto T, Usui T, et al. (2004). „Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta.”. Jpn. J. Ophthalmol. 47 (6): 557—64. PMID 14636845. doi:10.1016/j.jjo.2003.09.001. 
  • Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM (2006). „Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells.”. Biochim. Biophys. Acta. 1760 (6): 890—5. PMID 16564133. doi:10.1016/j.bbagen.2006.02.002. 
  • Campo GM, Avenoso A, Campo S, et al. (2007). „TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate.”. Mol. Cell. Biochem. 292 (1–2): 169—78. PMID 16786194. S2CID 37598580. doi:10.1007/s11010-006-9230-7. 
  • п
  • р
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2.4.1: Heksozil-
transferaze
Glukozil-
Galaktozil-
Glukuronozil-
Fukozil-
Manozil-
2.4.2: Pentozil-
transferaze
Riboza
ADP-riboziltransferaza
Fosforiboziltransferaza
Drugi
Drugi
2.4.99: Sijalil
transferaze