CD81

CD81
Uygun yapılar
PDBOrtolog araması: PDBe RCSB
PDB kimlik kodlarının listesi

1G8Q, 1IV5, 3X0E, 5DFW, 5DFV

Tanımlayıcılar
Başka adlarCD81
Dış kimliklerOMIM: 186845 MGI: 1096398 HomoloGene: 20915 GeneCards: CD81
Gen yerleşimi (İnsan)
11. Kromozom (insan)
Krom.11. Kromozom (insan)[1]
11. Kromozom (insan)
CD81 için genom yerleşimi
CD81 için genom yerleşimi
Bant11p15.5Başlangıç2,376,177 bç[1]
Bitiş2,397,397 bç[1]
RNA ekspresyonu deseni
Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi• GO:0001948, GO:0016582 protein bağlanması
• MHC class II protein complex binding
• transferrin receptor binding
• virus receptor activity
• integrin binding
• cholesterol binding
• lipid binding
Hücresel bileşeni• integral component of membrane
• Vezikül
• membrane
• focal adhesion
• integral component of plasma membrane
• immunological synapse
• extracellular exosome
• Hücre zarı
• basolateral plasma membrane
Biyolojik süreci• positive regulation of 1-phosphatidylinositol 4-kinase activity
• GO:0034613 protein localization
• regulation of protein stability
• receptor internalization
• cellular response to low-density lipoprotein particle stimulus
• regulation of cell motility
• receptor-mediated virion attachment to host cell
• protein localization to lysosome
• cell surface receptor signaling pathway
• positive regulation of B cell proliferation
• positive regulation of cell population proliferation
• regulation of immune response
• positive regulation of peptidyl-tyrosine phosphorylation
• Viral giriş
• positive regulation of protein catabolic process in the vacuole
• cell population proliferation
• GO:0022415 viral process
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• regulation of complement activation
• humoral immune response mediated by circulating immunoglobulin
• protein localization to plasma membrane
• adaptive immune response
• immune system process
Kaynaklar:Amigo / QuickGO
Ortologlar
TürlerİnsanFare
Entrez

975

12520

Ensembl

ENSG00000110651

ENSMUSG00000037706

UniProt

P60033

P35762

RefSeq (mRNA)

NM_001297649
NM_004356

NM_133655

RefSeq (protein)

NP_001284578
NP_004347

NP_598416

Yerleşim (UCSC)Krom. 11: 2.38 – 2.4 Mbn/a
PubMed araması[2][3]
Vikiveri
İnsan'ı Gör/DüzenleFare'yi Gör/Düzenle

CD81 molekülü, ayrıca 81. Başkalaşım Kümesi olarak da bilinir, insanların 11. kromozomunda yer alan CD81 geni tarafından kodlanan bir proteindir.[4][5]

Kaynakça

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110651 - Ensembl, May 2017
  2. ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
  3. ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
  4. ^ "Entrez Gene: CD81 CD81 molecule". 13 Nisan 2010 tarihinde kaynağından arşivlendi. Erişim tarihi: 11 Şubat 2024. 
  5. ^ Andria ML, Hsieh CL, Oren R, Francke U, Levy S (August 1991). "Genomic organization and chromosomal localization of the TAPA-1 gene". Journal of Immunology. 147 (3). ss. 1030-6. doi:10.4049/jimmunol.147.3.1030. PMID 1650385. 5 Eylül 2004 tarihinde kaynağından arşivlendi. Erişim tarihi: 11 Şubat 2024. 

Ek okuma

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  • Nagira M, Imai T, Ishikawa I, ve diğerleri. (1994). "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression". Cell. Immunol. 157 (1). ss. 144-57. doi:10.1006/cimm.1994.1212. PMID 8039242. 
  • Virtaneva KI, Emi N, Marken JS, ve diğerleri. (1994). "Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins". Immunogenetics. 39 (5). ss. 329-34. doi:10.1007/BF00189229. PMID 8168850. 
  • Radford KJ, Thorne RF, Hersey P (1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma". Biochem. Biophys. Res. Commun. 222 (1). ss. 13-8. doi:10.1006/bbrc.1996.0690. PMID 8630057. 
  • Szöllósi J, Horejsí V, Bene L, ve diğerleri. (1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY". J. Immunol. 157 (7). ss. 2939-46. doi:10.4049/jimmunol.157.7.2939. PMID 8816400. 
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  • Berditchevski F, Chang S, Bodorova J, Hemler ME (1997). "Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6". J. Biol. Chem. 272 (46). ss. 29174-80. doi:10.1074/jbc.272.46.29174. PMID 9360995. 
  • Tachibana I, Bodorova J, Berditchevski F, ve diğerleri. (1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. 272 (46). ss. 29181-9. doi:10.1074/jbc.272.46.29181. PMID 9360996. 
  • Hu RJ, Lee MP, Connors TD, ve diğerleri. (1998). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes". Genomics. 46 (1). ss. 9-17. doi:10.1006/geno.1997.4981. PMID 9403053. 
  • Pileri P, Uematsu Y, Campagnoli S, ve diğerleri. (1998). "Binding of hepatitis C virus to CD81". Science. 282 (5390). ss. 938-41. Bibcode:1998Sci...282..938P. doi:10.1126/science.282.5390.938. PMID 9794763. 
  • Serru V, Le Naour F, Billard M, ve diğerleri. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (Pt 1). ss. 103-11. doi:10.1042/0264-6021:3400103. PMC 1220227 $2. PMID 10229664. 
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