POLD3

Available structures

PDB

Pretraga ortologa: PDBe RCSB

List of PDB id codes
1U76, 3E0J, 2N1G

Identifikatori

Alijasi

POLD3

Spoljašnji ID

OMIM: 611415 MGI: 1915217 HomoloGene: 38202 GeneCards: POLD3

Genska lokacija (miš)

Hr.	Chromosome 7 (mouse)^[1]

Band	7\|7 E2	Start	99,731,318 bp^[1]
Band	7\|7 E2	Kraj	99,770,772 bp^[1]

Obrazac RNK izražavanja

More reference expression data

Genska ontologija
Molecular function	• GO:0001948, GO:0016582 везивање за протеине плазме • DNA-directed DNA polymerase activity
Cellular component	• delta DNA polymerase complex • једро • Нуклеоплазма • цитоплазма
Biological process	• nucleotide-excision repair, DNA gap filling • DNA synthesis involved in DNA repair • репликација ДНК • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • telomere maintenance • DNA-dependent DNA replication • nucleotide-excision repair, DNA incision, 5'-to lesion • GO:0100026 поправка ДНК • cellular response to DNA damage stimulus • telomere maintenance via semi-conservative replication • DNA mismatch repair • DNA strand elongation involved in DNA replication • DNA synthesis involved in UV-damage excision repair
Sources:Amigo / QuickGO

Ortolozi

Vrste

Čovek

Miš

Entrez


10714


67967

Ensembl


ENSG00000077514


ENSMUSG00000030726

UniProt


Q15054


Q9EQ28

RefSeq (mRNA)


NM_006591 NM_001363597


NM_133692 NM_001368380

RefSeq (protein)


NP_006582 NP_001350526


NP_598453 NP_001355309

Location (UCSC)

n/a

Chr 7: 99.73 – 99.77 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Delta podjedinica 3 DNK polimeraze je enzim koji je kod ljudi kodiran POLD3 genom.^[4]^[5] Ona je komponenta kompleksa DNK polimeraze delta.

Interakcije

POLD3 formira interakcije sa PCNA.^[6]^[7]

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000030726 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (1999). „Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts”. Nucleic Acids Res. 27 (10): 2108—14. PMC 148430 . PMID 10219083. doi:10.1093/nar/27.10.2108.
^ „Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit”.
^ Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (2001). „Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta”. J. Biol. Chem. 276 (52): 49258—66. PMID 11595739. doi:10.1074/jbc.M106990200.
^ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200.

Literatura

Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1”. DNA Res. 1 (1): 27—35. PMID 7584026. doi:10.1093/dnares/1.1.27.
Zeng XR, Jiang Y, Zhang SJ, Hao H, Lee MY (1994). „DNA polymerase delta is involved in the cellular response to UV damage in human cells”. J. Biol. Chem. 269 (19): 13748—51. PMID 7910606.
Longley MJ, Pierce AJ, Modrich P (1997). „DNA polymerase delta is required for human mismatch repair in vitro”. J. Biol. Chem. 272 (16): 10917—21. PMID 9099749. doi:10.1074/jbc.272.16.10917.
Mo J, Liu L, Leon A, Mazloum N, Lee MY (2000). „Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA”. Biochemistry. 39 (24): 7245—54. PMID 10852724. doi:10.1021/bi0000871.
Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (2002). „Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta”. J. Biol. Chem. 276 (52): 49258—66. PMID 11595739. doi:10.1074/jbc.M106990200.
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200.
Pohler JR, Otterlei M, Warbrick E (2006). „An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit”. BMC Mol. Biol. 6: 17. PMC 1187890 . PMID 16000169. doi:10.1186/1471-2199-6-17.
Takemura M, Yoshida S, Akiyama T, Kitagawa M, Yamada Y (2006). „Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase”. Biochim. Biophys. Acta. 1764 (9): 1447—53. PMID 16935576. doi:10.1016/j.bbapap.2006.06.015.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). „Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635—48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.
Masuda Y, Suzuki M, Piao J, Gu Y, Tsurimoto T, Kamiya K (2007). „Dynamics of human replication factors in the elongation phase of DNA replication”. Nucleic Acids Res. 35 (20): 6904—16. PMC 2175312 . PMID 17932049. doi:10.1093/nar/gkm822.

DNK replikacija (Prokariotska, Eukariotska)

Separacija
i inicijacija

Prokariotska (inicijacija)	Prereplikacioni kompleks Cdc6 Helikaza (dnaA, dnaB, T7) · Primaza (dnaG)
Eukariotska (priprema u G1 fazi)	Prereplikacioni kompleks: Kompleks prepoznavanja mesta početka (ORC1, ORC2, ORC3, ORC4, ORC5, ORC6) · Održavanje minihromozoma (MCM2 · MCM3 · MCM4 · MCM5 · MCM6 · MCM7) · CDC6 Faktor licenciranja Autonomna replikaciona sekvenca Protein jednolančanog vezivanja (SSBP1, SSBP2, SSBP3, SSBP4) RNaza H (RNASEH1, RNASEH2A) Helikaza: HFM1 Primaza: PRIM1 · PRIM2
Oba	Početak replikacije/Ori/Replikon Replikaciona viljuška (zaostajući i vodeći lanci) · Okazakijev fragment · Prajmer

Replikacija

Prokariotska (elongacija)	DNK polimeraza III holoenzim (dnaC, dnaE, dnaH, dnaN, dnaQ, dnaT, dnaX, holA, holB, holC, holD, holE) · Replizom · DNK ligaza · DNK stega · Topoizomeraza (DNK giraza) Prokariotska DNK polimeraza: DNK polimeraza I (Klenov fragment)
Eukariotska (sinteza u S fazi)	Replikacioni faktor C (RFC1) · Endonukleaza prepusta (FEN1) · Topoizomeraza · Replikacioni protein A (RPA1) Eukariotska DNK polimeraza: delta (POLD1, POLD2, POLD3, POLD4) DNK stega (PCNA)
Oba	Kretanje: Procesivnost · DNK ligaza

Terminacija

Telomer: Telomeraza (TERT, TERC, DKC1)

B bsyn: dnk (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)