Mitogenom-aktivirana proteinska kinaza 1
| Mitogenom-aktivirana proteinska kinaza 1 | |||||||||||
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 PDB prikaz baziran na PDB: 1erk. | |||||||||||
| Dostupne strukture | |||||||||||
| 1erk, 1gol, 1pme, 1tvo, 1wzy, 2erk, 2fys, 2gph, 2ojg, 2oji, 2ojj, 3erk, 4erk | |||||||||||
| Identifikatori | |||||||||||
| Simboli | MAPK1; p38; ERK; p40; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p41; p41mapk | ||||||||||
| Vanjski ID | OMIM: 176948 MGI: 1346858 HomoloGene: 37670 GeneCards: MAPK1 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5594 | 26413 | |||||||||
| Ensembl | ENSG00000100030 | ENSMUSG00000063358 | |||||||||
| UniProt | P28482 | Q3UF82 | |||||||||
| RefSeq (mRNA) | NM_002745 | NM_001038663 | |||||||||
| RefSeq (protein) | NP_002736 | NP_001033752 | |||||||||
| Lokacija (UCSC) | Chr 22: 20.45 - 20.55 Mb | Chr 16: 16.9 - 16.96 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Mitogenom-aktivirana proteinska kinaza 1, takođe poznata kao MAPK1, p42MAPK, i ERK2, je enzim koji je kod ljudi kodiran MAPK1 genom.[1]
Funkcije
Protein kodiran ovim genom je član familije MAP kinaza. Mitogenom-aktivirane proteinske kinaze, su takođe poznate kao ekstracelularnim signalom regulisane kinaze (ERK). One deluju kao tačka integracije višestrukih biohemijskih signala, i učestvuju u širokom varijetetu ćelijskih procesa kao što su proliferacija, diferencijacija, i regulacija transkripcije i razvoja. Prirekvizit aktivacije ove kinaze je njena fosforilisana uzvodnim kinazama. Nakon aktivacije, ova kinaza se translocira u jedro stimulisanih ćelija, gde ona fosforiliše proteine jedra. Dve alternativno splajsovane transkriptne varijante, koje se razlikuju u netranskribovanim regionima, kodiraju isti protein.[2]
Interakcije
Za MAPK1 je bilo pokazano da interaguje sa TSC2,[3] PEA15,[4] DUSP1,[5][6] NEK2,[7] DUSP3,[8] STAT5A,[9][10] MAPK14,[11][12] FHL2,[13] TNIP1,[14] RPS6KA3,[15][16] RPS6KA2,[15][17] MAP2K1,[11][18][19][20][21][22] RPS6KA1,[16][17][23] PTPN7,[24][25] MKNK1,[26] CIITA,[27] TOB1,[28] Fosfatidiletanolamin vezujući protein 1,[19] DUSP22,[29] Myc,[30][31][32] ADAM17,[33] SORBS3,[34] ELK1,[23][35] VAV1,[36][37] HDAC4,[38] MKNK2,[26][39] MAP3K1[40] i UBR5.[23]
Vidi još
Reference
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Literatura
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Spoljašnje veze
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PDB Galerija
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1erk: Struktura signalom regulisane kinaze -
1gol: MAP kinaza (ERK2) pacova sa arginin mutacijom u poziciji 52 -
1pme: Struktura penta mutanta ljudske ERK2 MAP kinaze u kompleksu sa specifičnim inhibitorom ljudske p38 MAP kinaze -
1tvo: ERK2 struktura u kompleksu sa inhibitorom -
1wzy: Kristalna struktura ljudske ERK2 kinaze u kompleksu sa pirazolopiridazin derivatom -
2erk: Fosforilisana MAP kinaza ERK2 -
2fys: Kristalna struktura of Erk2 u kompleksu sa KIM peptidom izvedenim iz MKP3 -
2gph: Doking motiv interakcija MAP kinaze ERK2 -
2ojg: Kristalna struktura ERK2 u kompleksu sa N,N-dimetil-4-(4-fenil-1H-pirazol-3-il)-1H-pirol-2-karboksamidom -
2oji: Kristalna struktura ERK2 u kompleksu sa N-benzil-4-(4-(3-hlorofenil)-1H-pirazol-3-il)-1H-pirol-2-carboksamid -
2ojj: Kristalna struktura ERK2 u kompleksu sa (S)-N-(1-(3-hloro-4-fluorofenil)-2-hidroksietil)-4-(4-(3-hlorofenil)-1H-pirazol-3-il)-1H-pirol-2-larboksamid -
3erk: Kompleks strukture MAP kinaze ERK2/SB220025 -
4erk: Kompleks strukture MAP kinaze ERK2/OLOMOUCINE
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