Glutamat-cisteinska ligaza
| Glutamat-cisteinska ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.2 | ||||||||
| CAS broj | 9023-64-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glutamat-cisteinska ligaza (EC 6.3.2.2, gama-glutamilcisteinska sintetaza, gama-glutamil-L-cistein sintetaza, gama-glutamilcisteinilna sintetaza) je enzim sa sistematskim imenom L-glutamat:L-cistein gama-ligaza (formira ADP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + L-glutamat + L-cistein ADP + fosfat + gama-L-glutamil-L-cistein
Ovaj enzim može da koristi L-aminoheksanoat umesto glutamata.
Reference
- ↑ MacKinnon, C.M., Carter, P.E., Smyth, S.J., Dunbar, B. and Fothergill, J.E. (1987). „Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence”. Eur. J. Biochem. 169: 547-553. PMID 3500856.
- ↑ Snoke, J.E., Yanari, S. and Bloch, K. (1953). „Synthesis of glutathione from γ-glutamylcysteine”. J. Biol. Chem. 201: 573-586. PMID 13061393.
- ↑ Mandeles, S. and Bloch, K. (1955). „Enzymatic synthesis of γ-glutamylcysteine”. J. Biol. Chem. 214: 639-646. PMID 14381401.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Glutamate---cysteine+ligase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
