GPRC6A

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G protein spregnuti receptor, familija C, grupa 6, član A

Identifikatori

GPRC6A; GPCR; bA86F4.3

Vanjski ID

OMIM: 613572 MGI: 2429498 HomoloGene: 17529 IUPHAR: GPRC₆ GeneCards: GPRC6A Gene

Ontologija gena
Molekularna funkcija	• aktivnost G-protein spregnutog receptora
Celularna komponenta	• ćelijska membrana • ćelijska površina • integralno sa membranom
Biološki proces	• kalcijum posredovan signalizacija • respons na aminokiselinski stimulus

Ortolozi

Vrsta

Čovek

Miš

Entrez

222545

210198

Ensembl

ENSG00000173612

ENSMUSG00000019905

UniProt

Q5T6X5

Q8K4Z6

RefSeq (mRNA)

NM_148963.2

NM_153071.1

RefSeq (protein)

NP_683766.2

NP_694711.1

Lokacija (UCSC)

Chr 6:
117.11 - 117.15 Mb

Chr 10:
51.33 - 51.35 Mb

PubMed pretraga

[1]

[2]

G protein spregnuti receptor familija C group 6 član A je protein koji je kod ljudi kodiran GPRC6A genom.^[1] Ovaj receptor funkcioniše kao senzor L-aminokiselina,^[2] osteokalcina,^[3] i steroida.^[4]

Klinički značaj

GPRC6A je takođe povezan sa progresijom raka prostate, i pokazano je da posreduje brz, negenomiski respons ćelija kancera prostate na testosteron.^[5]

Reference

↑ „Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A”.
↑ Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). „Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids”. Mol. Pharmacol. 67 (3): 589–97. DOI:10.1124/mol.104.007559. PMID 15576628.
↑ Pi M, Wu Y, Quarles LD (July 2011). „GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo”. J. Bone Miner. Res. 26 (7): 1680–3. DOI:10.1002/jbmr.390. PMID 21425331.
↑ Pi M, Parrill AL, Quarles LD (December 2010). „GPRC6A mediates the non-genomic effects of steroids”. J. Biol. Chem. 285 (51): 39953–64. DOI:10.1074/jbc.M110.158063. PMID 20947496.
↑ Pi M, Quarles LD (June 2011). „GPRC6A regulates prostate cancer progression”. Prostate 72 (4): 399–409. DOI:10.1002/pros.21442. PMID 21681779.

Literatura

Harrington JJ, Sherf B, Rundlett S, et al. (2001). „Creation of genome-wide protein expression libraries using random activation of gene expression.”. Nat. Biotechnol. 19 (5): 440–5. DOI:10.1038/88107. PMID 11329013.
Takeda S, Kadowaki S, Haga T, et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence.”. FEBS Lett. 520 (1–3): 97–101. DOI:10.1016/S0014-5793(02)02775-8. PMID 12044878.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
Wellendorph P, Bräuner-Osborne H (2004). „Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor”. Gene 335: 37–46. DOI:10.1016/j.gene.2004.03.003. PMID 15194188.
Wellendorph P, Hansen KB, Balsgaard A, et al. (2005). „Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids”. Mol. Pharmacol. 67 (3): 589–97. DOI:10.1124/mol.104.007559. PMID 15576628.
Pi M, Faber P, Ekema G, et al. (2006). „Identification of a novel extracellular cation-sensing G-protein-coupled receptor”. J. Biol. Chem. 280 (48): 40201–9. DOI:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532.

Spoljašnje veze

MeSH GPRC6A+protein,+human
„Calcium-Sensing Receptors: GPRC₆”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

Transmembranski receptor: G protein spregnuti receptori

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Orfan

GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)

Drugi

Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4)

Klasa F:
Frizzled / Zaglađeni

Uvojiti	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni	Zaglađeni

B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)