EPH receptor A3
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| EPH receptor A3 | |||||||||||
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 PDB prikaz baziran na 2gsf. | |||||||||||
| Dostupne strukture | |||||||||||
| 2GSF, 2QO2, 2QO7, 2QO9, 2QOB, 2QOC, 2QOD, 2QOF, 2QOI, 2QOK, 2QOL, 2QON, 2QOO, 2QOQ, 3DZQ, 3FXX, 3FY2, 4G2F, 4GK2, 4GK3, 4GK4 | |||||||||||
| Identifikatori | |||||||||||
| Simboli | EPHA3; EK4; ETK; ETK1; HEK; HEK4; TYRO4 | ||||||||||
| Vanjski ID | OMIM: 179611 MGI: 99612 HomoloGene: 21083 GeneCards: EPHA3 Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2042 | 13837 | |||||||||
| Ensembl | ENSG00000044524 | ENSMUSG00000052504 | |||||||||
| UniProt | P29320 | P29319 | |||||||||
| Ref. Sekv. (iRNK) | NM_005233 | NM_010140 | |||||||||
| Ref. Sekv. (protein) | NP_005224 | NP_034270 | |||||||||
| Lokacija (UCSC) | Chr 3: 89.16 - 89.53 Mb | Chr 16: 63.54 - 63.86 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
EPH receptor A3 (efrinski receptor 3 tipa A) protein je koji je kod ljudi kodiran EPHA3 genom.[1][2][3]
Ovaj gen je pripadnik grupe efrinskih receptora iz familije proteinskih turozinskih kinaza. EPH i EPH-srodni receptori uzimaju učešća u posredovanju događaja razvića, posebno u nervnom sistemu. Receptori EPH podfamilije tipično imaju jedan kinazni domen, ekstracelularni region koji sadrži domen bogat cisteinom i dva ponavljanja fibronektinskog tipa III. Efrinski receptori se dele u dve grupe na bazi sličnosti sekvenci njihovih ekstracelularnih domena i njihovih afiniteta vezivanja liganda efrina A i efrina B.[3]
Interakcije
EPH receptor A3 formira interakcije sa EFNB2[4][5] i EFNA5.[5][6]
Reference
- ↑ Boyd AW, Ward LD, Wicks IP, Simpson RJ, Salvaris E, Wilks A, Welch K, Loudovaris M, Rockman S, Busmanis I (March 1992). „Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line”. J Biol Chem 267 (5): 3262–7. PMID 1737782.
- ↑ Wicks IP, Wilkinson D, Salvaris E, Boyd AW (April 1992). „Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines”. Proc Natl Acad Sci U S A 89 (5): 1611–5. DOI:10.1073/pnas.89.5.1611. PMC 48502. PMID 1311845.
- ↑ 3,0 3,1 „Entrez Gene: EPHA3 EPH receptor A3”.
- ↑ Cerretti, D P; Vanden Bos T; Nelson N; Kozlosky C J; Reddy P; Maraskovsky E; Park L S; Lyman S D i dr.. (November 1995). „Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases”. Mol. Immunol. (ENGLAND) 32 (16): 1197–205. DOI:10.1016/0161-5890(95)00108-5. ISSN 0161-5890. PMID 8559144.
- ↑ 5,0 5,1 Lackmann, M; Mann R J, Kravets L, Smith F M, Bucci T A, Maxwell K F, Howlett G J, Olsson J E, Vanden Bos T, Cerretti D P, Boyd A W (June 1997). „Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor”. J. Biol. Chem. (UNITED STATES) 272 (26): 16521–30. DOI:10.1074/jbc.272.26.16521. ISSN 0021-9258. PMID 9195962.
- ↑ Kozlosky, C J; VandenBos T; Park L; Cerretti D P; Carpenter M K (August 1997). „LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain”. Cytokine (UNITED STATES) 9 (8): 540–9. DOI:10.1006/cyto.1997.0199. ISSN 1043-4666. PMID 9245480.
Literatura
- Flanagan JG, Vanderhaeghen P (1998). „The ephrins and Eph receptors in neural development.”. Annu. Rev. Neurosci. 21: 309–45. DOI:10.1146/annurev.neuro.21.1.309. PMID 9530499.
- Zhou R (1998). „The Eph family receptors and ligands.”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626.
- Ernst AF, Jurney WM, McLoon SC (1999). „Mechanisms involved in development of retinotectal connections: roles of Eph receptor tyrosine kinases, NMDA receptors and nitric oxide.”. Prog. Brain Res. 118: 115–31. DOI:10.1016/S0079-6123(08)63204-5. PMID 9932438.
- Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis.”. Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly.”. Int. Rev. Cytol. 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). „Roles of Eph receptors and ephrins in segmental patterning.”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. DOI:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
- Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development.”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076.
- Beckmann MP, Cerretti DP, Baum P, et al. (1994). „Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.”. EMBO J. 13 (16): 3757–62. PMC 395287. PMID 8070404.
- Wicks IP, Lapsys NM, Baker E, et al. (1994). „Localization of a human receptor tyrosine kinase (ETK1) to chromosome region 3p11.2.”. Genomics 19 (1): 38–41. DOI:10.1006/geno.1994.1009. PMID 8188238.
- Cerretti DP, Vanden Bos T, Nelson N, et al. (1996). „Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases.”. Mol. Immunol. 32 (16): 1197–205. DOI:10.1016/0161-5890(95)00108-5. PMID 8559144.
- Lackmann M, Mann RJ, Kravets L, et al. (1997). „Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor.”. J. Biol. Chem. 272 (26): 16521–30. DOI:10.1074/jbc.272.26.16521. PMID 9195962.
- Kozlosky CJ, VandenBos T, Park L, et al. (1997). „LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain.”. Cytokine 9 (8): 540–9. DOI:10.1006/cyto.1997.0199. PMID 9245480.
- Ephnomenclaturecommittee, (1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020.
- Lackmann M, Oates AC, Dottori M, et al. (1998). „Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization.”. J. Biol. Chem. 273 (32): 20228–37. DOI:10.1074/jbc.273.32.20228. PMID 9685371.
- Ciossek T, Monschau B, Kremoser C, et al. (1998). „Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro.”. Eur. J. Neurosci. 10 (5): 1574–80. DOI:10.1046/j.1460-9568.1998.00180.x. PMID 9751130.
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