ガルノン

ガルノン
IUPAC命名法による物質名
  • 9H-fluoren-9-ylmethyl N-[(2S)-1-([(2S)-6-amino-1-[(4-methyl-2-oxochromen-7- yl)amino]-1-oxohexan-2-yl]amino)-3-cyclohexyl-1-oxopropan-2-yl]carbamate
識別
CAS番号
 475115-35-6 チェック
PubChem CID: 5311268
ChemSpider 4470781 ×
ChEMBL CHEMBL592414 ×
化学的データ
化学式C40H46N4O6
分子量678.815
  • Cc3cc(=O)oc6cc(ccc36)NC(=O)C(CCCCN)NC(=O)C(CC5CCCCC5)NC(=O)OCC1c2ccccc2-c4c1cccc4
  • InChI=1S/C40H46N4O6/c1-25-21-37(45)50-36-23-27(18-19-28(25)36)42-38(46)34(17-9-10-20-41)43-39(47)35(22-26-11-3-2-4-12-26)44-40(48)49-24-33-31-15-7-5-13-29(31)30-14-6-8-16-32(30)33/h5-8,13-16,18-19,21,23,26,33-35H,2-4,9-12,17,20,22,24,41H2,1H3,(H,42,46)(H,43,47)(H,44,48)/t34-,35-/m0/s1 ×
  • Key:IKNOZZKXIDSTRN-PXLJZGITSA-N ×
テンプレートを表示

ガルノン(Galnon)は、ガラニン受容体GALRの選択的アゴニストである[1][2]。動物実験では、抗てんかん薬、抗不安薬、食欲減退薬、健忘の効果が見られた[3][4][5][6][7]。

出典

  1. ^ Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hökfelt T, Wasterlain C, Bartfai T, Langel U (May 2002). “Anticonvulsant activity of a nonpeptide galanin receptor agonist”. Proceedings of the National Academy of Sciences of the United States of America 99 (10): 7136–41. doi:10.1073/pnas.102163499. PMC 124541. PMID 12011470. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC124541/. 
  2. ^ Sollenberg U, Bartfai T, Langel U (June 2005). “Galnon--a low-molecular weight ligand of the galanin receptors”. Neuropeptides 39 (3): 161–3. doi:10.1016/j.npep.2004.12.019. PMID 15944006. 
  3. ^ Abramov U, Florén A, Echevarria DJ, Brewer A, Manuzon H, Robinson JK, Bartfai T, Vasar E, Langel U (February 2004). “Regulation of feeding by galnon”. Neuropeptides 38 (1): 55–61. doi:10.1016/j.npep.2004.01.001. PMID 15003717. 
  4. ^ Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (June 2005). “Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice”. Neuropeptides 39 (3): 249–51. doi:10.1016/j.npep.2004.12.010. PMID 15944018. 
  5. ^ Rajarao SJ, Platt B, Sukoff SJ, Lin Q, Bender CN, Nieuwenhuijsen BW, Ring RH, Schechter LE, Rosenzweig-Lipson S, Beyer CE (October 2007). “Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon”. Neuropeptides 41 (5): 307–20. doi:10.1016/j.npep.2007.05.001. PMID 17637475. 
  6. ^ Kozlovsky N, Matar MA, Kaplan Z, Zohar J, Cohen H (March 2009). “The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder”. Biological Psychiatry 65 (5): 383–91. doi:10.1016/j.biopsych.2008.10.034. PMID 19095221. 
  7. ^ Narasimhaiah R, Kamens HM, Picciotto MR (May 2009). “Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice”. Psychopharmacology 204 (1): 95–102. doi:10.1007/s00213-008-1438-7. PMC 2872184. PMID 19099295. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872184/.