TTC4

Protein-coding gene in the species Homo sapiens
TTC4
Identifiers
AliasesTTC4, tetratricopeptide repeat domain 4, CNS1
External IDsOMIM: 606753; MGI: 1919604; HomoloGene: 31249; GeneCards: TTC4; OMA:TTC4 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TTC4
Genomic location for TTC4
Band1p32.3Start54,715,861 bp[1]
End54,742,657 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for TTC4
Genomic location for TTC4
Band4|4 C7Start106,519,453 bp[2]
End106,536,141 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • islet of Langerhans

  • muscle of thigh

  • skeletal muscle tissue

  • C1 segment

  • pituitary gland

  • anterior pituitary

  • testicle

  • ventricular zone

  • apex of heart
Top expressed in
  • spermatocyte

  • spermatid

  • neural layer of retina

  • seminiferous tubule

  • ventricular zone

  • neural tube

  • muscle of thigh

  • right kidney

  • superior frontal gyrus

  • cerebellar cortex
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

7268

72354

Ensembl

ENSG00000243725

ENSMUSG00000025413

UniProt

O95801

Q8R3H9

RefSeq (mRNA)

NM_004623
NM_001291333

NM_001172073
NM_028209

RefSeq (protein)

NP_001278262
NP_004614

NP_001165544
NP_082485

Location (UCSC)Chr 1: 54.72 – 54.74 MbChr 4: 106.52 – 106.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tetratricopeptide repeat protein 4 is a protein that in humans is encoded by the TTC4 gene.[5][6]

The 34-amino acid tetratricopeptide repeat (TPR) motif is found in a variety of proteins and may mediate protein-protein or protein-membrane interactions.[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000243725 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025413 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Su G, Roberts T, Cowell JK (Sep 1999). "TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer". Genomics. 55 (2): 157–63. doi:10.1006/geno.1998.5633. PMID 9933562.
  6. ^ a b "Entrez Gene: TTC4 tetratricopeptide repeat domain 4".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lan S, Wang H, Jiang H, et al. (2003). "Direct interaction between alpha-actinin and hepatitis C virus NS5B". FEBS Lett. 554 (3): 289–94. doi:10.1016/S0014-5793(03)01163-3. PMID 14623081.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hey Y, Brintnell B, James LA, Varley JM (2000). "Assignment of TTC4 to human chromosome band 1p31.3 and a pseudogene TTC4P to 7p14→p13 by in situ hybridization". Cytogenet. Cell Genet. 88 (3–4): 272–4. doi:10.1159/000015536. PMID 10828607. S2CID 34754868.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.