TINAG

Protein-coding gene in the species Homo sapiens
TINAG
Identifiers
AliasesTINAG, TIN-AG, tubulointerstitial nephritis antigen
External IDsOMIM: 606749; MGI: 1349477; HomoloGene: 8082; GeneCards: TINAG; OMA:TINAG - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for TINAG
Genomic location for TINAG
Band6p12.1Start54,307,859 bp[1]
End54,390,142 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for TINAG
Genomic location for TINAG
Band9|9 DStart76,858,975 bp[2]
End76,953,076 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of ileum

  • human kidney

  • rectum

  • mucosa of transverse colon

  • jejunal mucosa

  • mucosa of sigmoid colon

  • testicle

  • duodenum

  • renal cortex

  • gallbladder
Top expressed in
  • human kidney

  • right kidney

  • Paneth cell

  • left lung lobe

  • efferent ductule

  • left colon

  • ileum

  • intestinal villus

  • jejunum

  • duodenum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • scavenger receptor activity
  • nucleotide binding
  • cysteine-type endopeptidase activity
  • polysaccharide binding
  • cysteine-type peptidase activity
Cellular component
  • basement membrane
  • extracellular region
  • lysosome
  • extracellular space
Biological process
  • cell adhesion
  • proteolysis involved in cellular protein catabolic process
  • receptor-mediated endocytosis
  • immune response
  • proteolysis
  • vesicle-mediated transport
  • endocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27283

26944

Ensembl

ENSG00000137251

ENSMUSG00000032357

UniProt

Q9UJW2

n/a

RefSeq (mRNA)

NM_014464

NM_012033

RefSeq (protein)

NP_055279

n/a

Location (UCSC)Chr 6: 54.31 – 54.39 MbChr 9: 76.86 – 76.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulointerstitial nephritis antigen is a protein that in humans is encoded by the TINAG gene.[5][6]

TINAG is a basement membrane glycoprotein initially identified as a target of antibodies in some forms of immunologically mediated tubulointerstitial nephritis.[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137251 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032357 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ikeda M, Takemura T, Hino S, Yoshioka K (Mar 2000). "Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen". Biochem Biophys Res Commun. 268 (1): 225–30. doi:10.1006/bbrc.2000.2103. PMID 10652240.
  6. ^ a b "Entrez Gene: TINAG tubulointerstitial nephritis antigen".

Further reading

  • Katz A, Fish AJ, Santamaria P, et al. (1993). "Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy". Am. J. Med. 93 (6): 691–8. doi:10.1016/0002-9343(92)90205-P. PMID 1466368.
  • Butkowski RJ, Kleppel MM, Katz A, et al. (1992). "Distribution of tubulointerstitial nephritis antigen and evidence for multiple forms". Kidney Int. 40 (5): 838–46. doi:10.1038/ki.1991.283. PMID 1762287.
  • Fliger FD, Wieslander J, Brentjens JR, et al. (1987). "Identification of a target antigen in human anti-tubular basement membrane nephritis". Kidney Int. 31 (3): 800–7. doi:10.1038/ki.1987.69. PMID 3553704.
  • Chen Y, Krishnamurti U, Wayner EA, et al. (1996). "REceptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen". Kidney Int. 49 (1): 153–7. doi:10.1038/ki.1996.20. PMID 8770961.
  • Nelson TR, Kim Y, Michael AF, et al. (1999). "Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron". Connect. Tissue Res. 37 (1–2): 53–60. doi:10.3109/03008209809028899. PMID 9643646.
  • Kim SH, Kaminker P, Campisi J (1999). "TIN2, a new regulator of telomere length in human cells". Nat. Genet. 23 (4): 405–12. doi:10.1038/70508. PMC 4940194. PMID 10581025.
  • Zhou B, Nelson TR, Kashtan C, et al. (2000). "Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag)". J. Am. Soc. Nephrol. 11 (4): 658–68. doi:10.1681/ASN.V114658. PMID 10752525.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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