SNX17

Protein-coding gene in the species Homo sapiens

SNX17

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3FOG, 3LUI, 4GXB, 4TKN

Identifiers

Aliases

SNX17, sorting nexin 17

External IDs

OMIM: 605963; MGI: 2387801; HomoloGene: 8838; GeneCards: SNX17; OMA:SNX17 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p23.3	Start	27,370,496 bp^[1]
Band	2p23.3	End	27,377,535 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 B1	Start	31,350,571 bp^[2]
Band	5\|5 B1	End	31,356,487 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

granulocyte

right adrenal gland

right adrenal cortex

monocyte

left adrenal gland

left adrenal cortex

anterior pituitary

stromal cell of endometrium

right coronary artery

spleen

Top expressed in

medial ganglionic eminence

renal corpuscle

internal carotid artery

external carotid artery

epithelium of lens

Paneth cell

vestibular membrane of cochlear duct

Rostral migratory stream

endocardial cushion

median eminence

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	low-density lipoprotein particle receptor binding protein C-terminus binding protein binding phosphatidylinositol binding signaling receptor binding lipid binding
Cellular component	cytosol endosome Golgi apparatus membrane intracellular membrane-bounded organelle early endosome endosome membrane cytoplasmic vesicle membrane cytoplasm cytoplasmic vesicle protein-containing complex
Biological process	regulation of endocytosis cardiac septum development cholesterol catabolic process receptor-mediated endocytosis coronary vasculature development endosomal transport aorta development protein transport signal transduction intracellular protein transport endocytic recycling
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9784


266781

Ensembl


ENSG00000115234


ENSMUSG00000029146

UniProt


Q15036


Q8BVL3

RefSeq (mRNA)


NM_001267059 NM_001267060 NM_001267061 NM_014748


NM_153680

RefSeq (protein)


NP_001253988 NP_001253989 NP_001253990 NP_055563


NP_710147

Location (UCSC)

Chr 2: 27.37 – 27.38 Mb

Chr 5: 31.35 – 31.36 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.^[5]^[6]^[7]

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.^[7]

Interactions

SNX17 has been shown to interact with Low density lipoprotein receptor-related protein 8^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115234 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029146 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Stockinger W, Sailler B, Strasser V, Recheis B, Fasching D, Kahr L, Schneider WJ, Nimpf J (Aug 2002). "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor". EMBO J. 21 (16): 4259–67. doi:10.1093/emboj/cdf435. PMC 126172. PMID 12169628.
^ Knauth P, Schlüter T, Czubayko M, Kirsch C, Florian V, Schreckenberger S, Hahn H, Bohnensack R (Mar 2005). "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking". J. Mol. Biol. 347 (4): 813–25. doi:10.1016/j.jmb.2005.02.004. PMID 15769472.
^ ^a ^b "Entrez Gene: SNX17 sorting nexin 17".

Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
Florian V, Schlüter T, Bohnensack R (2001). "A new member of the sorting nexin family interacts with the C-terminus of P-selectin". Biochem. Biophys. Res. Commun. 281 (4): 1045–50. doi:10.1006/bbrc.2001.4467. PMID 11237770.
Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Burden JJ, Sun XM, García AB, Soutar AK (2004). "Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin-17". J. Biol. Chem. 279 (16): 16237–45. doi:10.1074/jbc.M313689200. PMID 14739284.
Williams R, Schlüter T, Roberts MS, Knauth P, Bohnensack R, Cutler DF (2004). "Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin". Mol. Biol. Cell. 15 (7): 3095–105. doi:10.1091/mbc.E04-02-0143. PMC 452567. PMID 15121882.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman J, Bu G (2005). "Sorting nexin 17 facilitates LRP recycling in the early endosome". EMBO J. 24 (16): 2851–61. doi:10.1038/sj.emboj.7600756. PMC 1187941. PMID 16052210.
Czubayko M, Knauth P, Schlüter T, Florian V, Bohnensack R (2006). "Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1". Biochem. Biophys. Res. Commun. 345 (3): 1264–72. doi:10.1016/j.bbrc.2006.04.129. PMID 16712798.