SEC61G

Mammalian protein found in Homo sapiens
SEC61G
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2WWB, 3J7R, 4CG7, 3J7Q, 4CG5, 4CG6

Identifiers
AliasesSEC61G, SSS1, Sec61 translocon gamma subunit, SEC61 translocon subunit gamma
External IDsOMIM: 609215; MGI: 1202066; HomoloGene: 40767; GeneCards: SEC61G; OMA:SEC61G - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for SEC61G
Genomic location for SEC61G
Band7p11.2Start54,752,250 bp[1]
End54,759,974 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SEC61G
Genomic location for SEC61G
Band11|11 A2Start16,500,530 bp[2]
End16,508,484 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pituitary gland

  • body of pancreas

  • anterior pituitary

  • islet of Langerhans

  • mucosa of transverse colon

  • corpus epididymis

  • ganglionic eminence

  • cartilage tissue

  • tendon of biceps brachii

  • ventricular zone
Top expressed in
  • epiblast

  • primary oocyte

  • ileum

  • quadriceps femoris muscle

  • embryo

  • jejunum

  • bone marrow

  • embryo

  • neural tube

  • ventricular zone
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein-transporting ATPase activity
  • protein binding
  • protein transmembrane transporter activity
Cellular component
  • integral component of membrane
  • cytosol
  • endoplasmic reticulum membrane
  • membrane
  • endoplasmic reticulum
Biological process
  • protein targeting
  • protein transmembrane transport
  • protein targeting to ER
  • protein transport
  • intracellular protein transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23480

20335

Ensembl

ENSG00000132432

ENSMUSG00000078974

UniProt

P60059

P60060

RefSeq (mRNA)

NM_014302
NM_001012456

NM_001109971
NM_001109972
NM_011343

RefSeq (protein)

NP_001012474
NP_055117

NP_001103441
NP_001103442
NP_035473

Location (UCSC)Chr 7: 54.75 – 54.76 MbChr 11: 16.5 – 16.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein transport protein Sec61 subunit gamma is a protein that in humans is encoded by the SEC61G gene.[5][6][7]

Function

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132432 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078974 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hartmann E, Sommer T, Prehn S, Görlich D, Jentsch S, Rapoport TA (February 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. Bibcode:1994Natur.367..654H. doi:10.1038/367654a0. PMID 8107851. S2CID 4323463.
  6. ^ Greenfield JJ, High S (May 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". Journal of Cell Science. 112 ( Pt 10) (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID 10212142.
  7. ^ a b "Entrez Gene: SEC61G Sec61 gamma subunit".

Further reading

  • Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL (December 1996). "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature. 384 (6608): 432–8. Bibcode:1996Natur.384..432W. doi:10.1038/384432a0. PMID 8945469. S2CID 6276718.
  • Chen Y, Le Cahérec F, Chuck SL (May 1998). "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex". The Journal of Biological Chemistry. 273 (19): 11887–94. doi:10.1074/jbc.273.19.11887. PMID 9565615.
  • Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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