RIPK2 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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4C8B, 2N7Z, 5AR3, 5AR2, 5AR7, 5AR8, 5AR5, 5AR4, 2N83, 5J7B, 5J79 |
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Identifiers |
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Aliases | RIPK2, CARD3, CARDIAK, CCK, GIG30, RICK, RIP2, receptor interacting serine/threonine kinase 2 |
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External IDs | OMIM: 603455; MGI: 1891456; HomoloGene: 37856; GeneCards: RIPK2; OMA:RIPK2 - orthologs |
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EC number | 2.7.10.2 |
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Gene location (Human) |
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![Chromosome 8 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/6/60/Ideogram_human_chromosome_8.svg/300px-Ideogram_human_chromosome_8.svg.png) | Chr. | Chromosome 8 (human)[1] |
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| Band | 8q21.3 | Start | 89,757,806 bp[1] |
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End | 89,791,064 bp[1] |
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Gene location (Mouse) |
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![Chromosome 4 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/260px-Ideogram_house_mouse_chromosome_4.svg.png) | Chr. | Chromosome 4 (mouse)[2] |
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| Band | 4 A2|4 6.7 cM | Start | 16,122,733 bp[2] |
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End | 16,163,647 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - cartilage tissue
- monocyte
- gonad
- vena cava
- bone marrow
- stromal cell of endometrium
- granulocyte
- gallbladder
- skin of arm
- oocyte
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| Top expressed in | - zygote
- esophagus
- genital tubercle
- secondary oocyte
- tibiofemoral joint
- tail of embryo
- embryo
- lens
- granulocyte
- primary oocyte
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/6/64/PBB_GE_RIPK2_209545_s_at_fs.png/250px-PBB_GE_RIPK2_209545_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/3/3a/PBB_GE_RIPK2_209544_at_fs.png/250px-PBB_GE_RIPK2_209544_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - LIM domain binding
- kinase activity
- CARD domain binding
- signaling receptor binding
- ATP binding
- protein kinase activity
- non-membrane spanning protein tyrosine kinase activity
- transferase activity
- protein homodimerization activity
- protein binding
- nucleotide binding
- signal transducer activity
- protein serine/threonine kinase activity
- identical protein binding
- caspase binding
- JUN kinase kinase kinase activity
| Cellular component | - cytoplasm
- cytoskeleton
- vesicle
- cytosol
- protein-containing complex
| Biological process | - response to interleukin-1
- positive regulation of cytokine-mediated signaling pathway
- response to exogenous dsRNA
- positive regulation of JNK cascade
- positive regulation of xenophagy
- cellular response to muramyl dipeptide
- protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- cellular response to peptidoglycan
- positive regulation of stress-activated MAPK cascade
- defense response to Gram-positive bacterium
- apoptotic process
- regulation of apoptotic process
- positive regulation of immature T cell proliferation
- positive regulation of interleukin-12 production
- positive regulation of interferon-alpha production
- positive regulation of peptidyl-serine phosphorylation
- JNK cascade
- response to interleukin-12
- nucleotide-binding oligomerization domain containing 2 signaling pathway
- positive regulation of T-helper 1 type immune response
- positive regulation of alpha-beta T cell proliferation
- positive regulation of interleukin-6 production
- positive regulation of tumor necrosis factor production
- positive regulation of peptidyl-tyrosine phosphorylation
- inflammatory response
- I-kappaB kinase/NF-kappaB signaling
- nucleotide-binding oligomerization domain containing 1 signaling pathway
- positive regulation of interferon-beta production
- phosphorylation
- immune system process
- positive regulation of T-helper 1 cell differentiation
- negative regulation of apoptotic process
- cellular response to lipoteichoic acid
- positive regulation of interleukin-2 production
- positive regulation of chemokine production
- nucleotide-binding oligomerization domain containing signaling pathway
- positive regulation of protein ubiquitination
- lipopolysaccharide-mediated signaling pathway
- positive regulation of interferon-gamma production
- T cell proliferation
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of apoptotic process
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- peptidyl-tyrosine phosphorylation
- cellular response to lipopolysaccharide
- T cell receptor signaling pathway
- response to interleukin-18
- signal transduction
- positive regulation of transcription by RNA polymerase II
- toll-like receptor 4 signaling pathway
- toll-like receptor 2 signaling pathway
- innate immune response
- MAPK cascade
- adaptive immune response
- positive regulation of protein binding
- positive regulation of NF-kappaB transcription factor activity
- activation of cysteine-type endopeptidase activity
- positive regulation of cell death
- interleukin-1-mediated signaling pathway
| Sources:Amigo / QuickGO |
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Wikidata |
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