PDZRN3

Protein-coding gene in the species Homo sapiens
PDZRN3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1UHP, 1WH1

Identifiers
AliasesPDZRN3, LNX3, SEMACAP3, SEMCAP3, PDZ domain containing ring finger 3
External IDsOMIM: 609729; MGI: 1933157; HomoloGene: 10328; GeneCards: PDZRN3; OMA:PDZRN3 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for PDZRN3
Genomic location for PDZRN3
Band3p13Start73,382,431 bp[1]
End73,624,941 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for PDZRN3
Genomic location for PDZRN3
Band6|6 D3Start101,126,570 bp[2]
End101,354,858 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • hair follicle

  • gastric mucosa

  • urethra

  • vastus lateralis muscle

  • seminal vesicula

  • cartilage tissue

  • saphenous vein

  • myocardium of left ventricle

  • right ventricle

  • tibia
Top expressed in
  • molar

  • soleus muscle

  • tibialis anterior muscle

  • vastus lateralis muscle

  • gastrocnemius muscle

  • belly cord

  • atrioventricular valve

  • medial head of gastrocnemius muscle

  • triceps brachii muscle

  • sternocleidomastoid muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • zinc ion binding
  • metal ion binding
  • ubiquitin protein ligase activity
  • ubiquitin-protein transferase activity
  • transferase activity
Cellular component
  • neuromuscular junction
  • nucleus
  • nucleoplasm
  • cytosol
  • cytoplasm
  • cell junction
  • synapse
Biological process
  • neuromuscular junction development
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23024

55983

Ensembl

ENSG00000121440

ENSMUSG00000035357

UniProt

Q9UPQ7

Q69ZS0

RefSeq (mRNA)

NM_015009
NM_001303139
NM_001303140
NM_001303141
NM_001303142

NM_018884

RefSeq (protein)

NP_001290068
NP_001290069
NP_001290070
NP_001290071
NP_055824

NP_061372

Location (UCSC)Chr 3: 73.38 – 73.62 MbChr 6: 101.13 – 101.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PDZ domain-containing RING finger protein 3 is a protein that in humans is encoded by the PDZRN3 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121440 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035357 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  6. ^ "Entrez Gene: PDZRN3 PDZ domain containing RING finger 3".

Further reading

  • Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247. S2CID 22326394.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Katoh M, Katoh M (2004). "Identification and characterization of PDZRN3 and PDZRN4 genes in silico". Int. J. Mol. Med. 13 (4): 607–13. doi:10.3892/ijmm.13.4.607. PMID 15010864.
  • Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402. S2CID 6773754.
  • Santin AD, Zhan F, Bellone S, et al. (2004). "Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy". Int. J. Cancer. 112 (1): 14–25. doi:10.1002/ijc.20408. PMID 15305371. S2CID 29845339.
  • Meyer G, Varoqueaux F, Neeb A, et al. (2005). "The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin". Neuropharmacology. 47 (5): 724–33. doi:10.1016/j.neuropharm.2004.06.023. PMID 15458844. S2CID 11771522.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • v
  • t
  • e
  • 1uhp: Solution structure of RSGI RUH-005, a PDZ domain in human cDNA, KIAA1095
    1uhp: Solution structure of RSGI RUH-005, a PDZ domain in human cDNA, KIAA1095
  • 1wh1: Solution structure of the fourth PDZ domain of KIAA1095 protein
    1wh1: Solution structure of the fourth PDZ domain of KIAA1095 protein


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