PCOLCE2

Protein-coding gene in the species Homo sapiens
PCOLCE2
Identifiers
AliasesPCOLCE2, PCPE2, procollagen C-endopeptidase enhancer 2
External IDsOMIM: 607064; MGI: 1923727; HomoloGene: 8357; GeneCards: PCOLCE2; OMA:PCOLCE2 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for PCOLCE2
Genomic location for PCOLCE2
Band3q23Start142,815,922 bp[1]
End142,889,206 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for PCOLCE2
Genomic location for PCOLCE2
Band9|9 E3.3Start95,519,654 bp[2]
End95,580,149 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • tibia

  • synovial joint

  • tendon of biceps brachii

  • glomerulus

  • right coronary artery

  • metanephric glomerulus

  • pericardium

  • right auricle

  • Descending thoracic aorta
Top expressed in
  • Epithelium of choroid plexus

  • right lung lobe

  • ascending aorta

  • skin of external ear

  • aortic valve

  • nasal epithelium

  • olfactory epithelium

  • carotid body

  • sciatic nerve

  • ankle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • heparin binding
  • peptidase activator activity
  • collagen binding
Cellular component
  • extracellular region
Biological process
  • positive regulation of peptidase activity
  • cellular response to leukemia inhibitory factor
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26577

76477

Ensembl

ENSG00000163710

ENSMUSG00000015354

UniProt

Q9UKZ9

Q8R4W6

RefSeq (mRNA)

NM_013363

NM_029620

RefSeq (protein)

NP_037495

NP_083896

Location (UCSC)Chr 3: 142.82 – 142.89 MbChr 9: 95.52 – 95.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Procollagen C-endopeptidase enhancer 2 is a protein that in humans is encoded by the PCOLCE2 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163710 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015354 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Xu H, Acott TS, Wirtz MK (Sep 2000). "Identification and expression of a novel type I procollagen C-proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24". Genomics. 66 (3): 264–73. doi:10.1006/geno.2000.6229. PMID 10873381.
  6. ^ "Entrez Gene: PCOLCE2 procollagen C-endopeptidase enhancer 2".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Kumar S, Connor JR, Dodds RA, et al. (2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries". Osteoarthr. Cartil. 9 (7): 641–53. doi:10.1053/joca.2001.0421. PMID 11597177.
  • Steiglitz BM, Greenspan DS (2002). "Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9 and localization of PCOLCE2 to human chromosome 3q23". Cytogenet. Cell Genet. 95 (3–4): 244–5. doi:10.1159/000059356. PMID 12063410. S2CID 7566205.
  • Steiglitz BM, Keene DR, Greenspan DS (2003). "PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1". J. Biol. Chem. 277 (51): 49820–30. doi:10.1074/jbc.M209891200. PMID 12393877.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.


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