PARD3B

Protein-coding gene in the species Homo sapiens

PARD3B

Identifiers

Aliases

PARD3B, ALS2CR19, PAR3B, PAR3L, PAR3LC, PAR3beta, Par3Lb, par-3 family cell polarity regulator beta

External IDs

MGI: 1919301; HomoloGene: 35389; GeneCards: PARD3B; OMA:PARD3B - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q33.3	Start	204,545,475 bp^[1]
Band	2q33.3	End	205,620,162 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 C2	Start	61,677,983 bp^[2]
Band	1\|1 C2	End	62,681,443 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

ventricular zone

Achilles tendon

epithelium of colon

saphenous vein

tibial arteries

mucosa of ileum

testicle

gonad

skin of hip

Top expressed in

Rostral migratory stream

crypt of lieberkuhn of small intestine

internal carotid artery

external carotid artery

sciatic nerve

lumbar spinal ganglion

renal corpuscle

ciliary body

iris

intestinal villus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding phosphatidylinositol binding
Cellular component	membrane endomembrane system bicellular tight junction cell junction nucleoplasm nuclear body protein-containing complex cytoplasm adherens junction cell cortex apical plasma membrane apical junction complex
Biological process	cell division cell cycle microtubule cytoskeleton organization cell adhesion protein localization establishment of cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment of centrosome localization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


117583


72823

Ensembl


ENSG00000116117


ENSMUSG00000052062

UniProt


Q8TEW8


Q9CSB4

RefSeq (mRNA)


NM_001302769 NM_057177 NM_152526 NM_205863


NM_001081050

RefSeq (protein)


NP_001289698 NP_476518 NP_689739 NP_995585


NP_001074519

Location (UCSC)

Chr 2: 204.55 – 205.62 Mb

Chr 1: 61.68 – 62.68 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Partitioning defective 3 homolog B is a protein that in humans is encoded by the PARD3B gene.^[5]^[6]^[7]

Interactions

PARD3B has been shown to interact with Mothers against decapentaplegic homolog 3.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116117 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052062 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298. S2CID 52828189.
^ Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem Biophys Res Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
^ "Entrez Gene: PARD3B par-3 partitioning defective 3 homolog B (C. elegans)".
^ Warner DR, Pisano M Michele, Roberts Emily A, Greene Robert M (Mar 2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3). Netherlands: 167–73. doi:10.1016/S0014-5793(03)00155-8. ISSN 0014-5793. PMID 12650946. S2CID 7429554.

Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Izaki T, Kamakura S, Kohjima M, Sumimoto H (2005). "Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human Par3-related cell polarity protein". Biochem. Biophys. Res. Commun. 329 (1): 211–8. doi:10.1016/j.bbrc.2005.01.115. PMID 15721295.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Warner DR, Pisano MM, Roberts EA, Greene RM (2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3): 167–73. doi:10.1016/S0014-5793(03)00155-8. PMID 12650946. S2CID 7429554.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID 12234671.