NEK8

Protein-coding gene in the species Homo sapiens
NEK8
Identifiers
AliasesNEK8, JCK, NEK12A, NPHP9, RHPD2, NIMA related kinase 8
External IDsOMIM: 609799; MGI: 1890646; HomoloGene: 84442; GeneCards: NEK8; OMA:NEK8 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for NEK8
Genomic location for NEK8
Band17q11.2Start28,725,897 bp[1]
End28,743,455 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for NEK8
Genomic location for NEK8
Band11 B5|11 46.74 cMStart78,056,932 bp[2]
End78,067,501 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • left lobe of thyroid gland

  • granulocyte

  • right lobe of thyroid gland

  • right uterine tube

  • lymph node

  • right adrenal cortex

  • monocyte

  • visceral pleura

  • testicle
Top expressed in
  • saccule

  • otic vesicle

  • lumbar spinal ganglion

  • spermatocyte

  • tail of embryo

  • right kidney

  • genital tubercle

  • proximal tubule

  • ventricular zone

  • granulocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • kinase activity
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • protein binding
  • ATP binding
  • metal ion binding
  • protein serine/threonine kinase activity
Cellular component
  • cytoplasm
  • ciliary base
  • cell projection
  • cytoskeleton
  • ciliary inversin compartment
  • cilium
Biological process
  • animal organ morphogenesis
  • heart development
  • regulation of hippo signaling
  • determination of left/right symmetry
  • phosphorylation
  • protein phosphorylation
  • cilium assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

284086

140859

Ensembl

ENSG00000160602

ENSMUSG00000017405

UniProt

Q86SG6

Q91ZR4

RefSeq (mRNA)

NM_178170

NM_080849

RefSeq (protein)

NP_835464

NP_543125

Location (UCSC)Chr 17: 28.73 – 28.74 MbChr 11: 78.06 – 78.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase Nek8, also known as never in mitosis A-related kinase 8, is an enzyme that in humans is encoded by the NEK8 gene.[5][6]

Function

Nek8 is a member of the serine/threonine-specific protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase.[5]

Clinical significance

Mutations in the NEK8 gene associated with nephronophthisis.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160602 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017405 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: NIMA (never in mitosis gene a)- related kinase 8".
  6. ^ Otto EA, Trapp ML, Schultheiss UT, Helou J, Quarmby LM, Hildebrandt F (March 2008). "NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis". J. Am. Soc. Nephrol. 19 (3): 587–92. doi:10.1681/ASN.2007040490. PMC 2391043. PMID 18199800.
  7. ^ Lancaster MA, Gleeson JG (June 2009). "The primary cilium as a cellular signaling center: lessons from disease". Curr. Opin. Genet. Dev. 19 (3): 220–9. doi:10.1016/j.gde.2009.04.008. PMC 2953615. PMID 19477114.
  8. ^ Zalli, D.; Bayliss, R.; Fry, A. M. (21 November 2011). "The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis". Human Molecular Genetics. 21 (5): 1155–1171. doi:10.1093/hmg/ddr544. PMC 3277313. PMID 22106379.

Further reading

  • Bowers AJ, Boylan JF (2004). "Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors". Gene. 328: 135–42. doi:10.1016/j.gene.2003.12.002. PMID 15019993.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Valkova N, Yunis R, Mak SK, et al. (2005). "Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice". Mol. Cell. Proteomics. 4 (7): 1009–18. doi:10.1074/mcp.M500091-MCP200. PMID 15872312.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Holland PM, Milne A, Garka K, et al. (2002). "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2". J. Biol. Chem. 277 (18): 16229–40. doi:10.1074/jbc.M108662200. PMID 11864968.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Simms RJ, Eley L, Sayer JA (2009). "Nephronophthisis". Eur. J. Hum. Genet. 17 (4): 406–16. doi:10.1038/ejhg.2008.238. PMC 2986221. PMID 19066617.
  • Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening". Proteomics. 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID 17474147. S2CID 22474278.
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Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
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IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
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Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
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Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
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Tropomyosin kinase (EC 2.7.11.28)
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
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Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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