Protein-coding gene in the species Homo sapiens
| AP1G2 |
|---|
|
| Available structures |
|---|
| PDB | Ortholog search: PDBe RCSB |
|---|
| List of PDB id codes |
|---|
2E9G, 2YMT, 3ZHF, 4BCX |
|
|
| Identifiers |
|---|
| Aliases | AP1G2, G2AD, adaptor related protein complex 1 gamma 2 subunit, adaptor related protein complex 1 subunit gamma 2 |
|---|
| External IDs | OMIM: 603534; MGI: 1328307; HomoloGene: 49141; GeneCards: AP1G2; OMA:AP1G2 - orthologs |
|---|
| Gene location (Human) |
|---|
 | | Chr. | Chromosome 14 (human)[1] |
|---|
| | Band | 14q11.2 | Start | 23,559,565 bp[1] |
|---|
| End | 23,568,070 bp[1] |
|---|
|
| Gene location (Mouse) |
|---|
 | | Chr. | Chromosome 14 (mouse)[2] |
|---|
| | Band | 14|14 C3 | Start | 55,336,032 bp[2] |
|---|
| End | 55,344,050 bp[2] |
|---|
|
| RNA expression pattern |
|---|
| Bgee | | Human | Mouse (ortholog) |
|---|
| Top expressed in | - right hemisphere of cerebellum
- granulocyte
- anterior pituitary
- right uterine tube
- right lobe of thyroid gland
- left lobe of thyroid gland
- right frontal lobe
- left ovary
- right ovary
- mucosa of transverse colon
|
| | Top expressed in | - duodenum
- yolk sac
- granulocyte
- jejunum
- otic vesicle
- lip
- ileum
- crypt of lieberkuhn of small intestine
- otic placode
- thymus
|
| | More reference expression data |
|
|---|
| BioGPS | |
|---|
|
| Gene ontology |
|---|
| Molecular function | | | Cellular component | - Golgi-associated vesicle
- membrane coat
- Golgi membrane
- endosome
- Golgi apparatus
- endosome membrane
- transport vesicle
- membrane
- cytoplasmic vesicle membrane
- cytoplasmic vesicle
- clathrin adaptor complex
- AP-1 adaptor complex
| | Biological process | - protein transport
- intracellular protein transport
- viral process
- vesicle-mediated transport
| | Sources:Amigo / QuickGO |
|
| Orthologs |
|---|
| Species | Human | Mouse |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (mRNA) | NM_001282474
NM_001282475
NM_003917
NM_080545
NM_001354673
|
|---|
NM_001354674
NM_001354675
NM_001354677
NM_001354681 |
| |
|---|
| RefSeq (protein) | NP_001269403
NP_001269404
NP_003908
NP_001341602
NP_001341603
|
|---|
NP_001341604
NP_001341606
NP_001341610 |
| |
|---|
| Location (UCSC) | Chr 14: 23.56 – 23.57 Mb | Chr 14: 55.34 – 55.34 Mb |
|---|
| PubMed search | [3] | [4] |
|---|
|
| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene.[5][6][7]
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. There are two alternatively spliced transcript variants of this gene encoding the same protein.[7]
Interactions
AP1G2 has been shown to interact with NEDD4.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000213983 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040701 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Oct 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J Biol Chem. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768.
- ^ Lewin DA, Sheff D, Ooi CE, Whitney JA, Yamamoto E, Chicione LM, Webster P, Bonifacino JS, Mellman I (Oct 1998). "Cloning, expression, and localization of a novel gamma-adaptin-like molecule". FEBS Lett. 435 (2–3): 263–8. Bibcode:1998FEBSL.435..263L. doi:10.1016/S0014-5793(98)01083-7. PMID 9762922. S2CID 83518205.
- ^ a b "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit".
- ^ Rost, Martina; Döring Tatjana; Prange Reinhild (Nov 2008). "gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway". J. Biol. Chem. 283 (46). United States: 32119–30. doi:10.1074/jbc.M802632200. ISSN 0021-9258. PMID 18772139.
External links
Further reading
- Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741.
- Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris). 19 (1): 100–6. doi:10.1051/medsci/2003191100. PMID 12836198.
- Craig HM, Pandori MW, Guatelli JC (1998). "Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11229–34. Bibcode:1998PNAS...9511229C. doi:10.1073/pnas.95.19.11229. PMC 21624. PMID 9736718.
- Bresnahan PA, Yonemoto W, Ferrell S, et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor". Curr. Biol. 8 (22): 1235–8. Bibcode:1998CBio....8.1235B. doi:10.1016/S0960-9822(07)00517-9. PMID 9811606.
- Greenberg M, DeTulleo L, Rapoport I, et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Curr. Biol. 8 (22): 1239–42. Bibcode:1998CBio....8.1239G. doi:10.1016/S0960-9822(07)00518-0. PMID 9811611.
- Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". J. Virol. 73 (2): 1350–61. doi:10.1128/JVI.73.2.1350-1361.1999. PMC 103959. PMID 9882340.
- Page LJ, Sowerby PJ, Lui WW, Robinson MS (1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". J. Cell Biol. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.
- Wyss S, Berlioz-Torrent C, Boge M, et al. (2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]". J. Virol. 75 (6): 2982–92. doi:10.1128/JVI.75.6.2982-2992.2001. PMC 115924. PMID 11222723.
- Hartmann-Stühler C, Prange R (2001). "Hepatitis B virus large envelope protein interacts with gamma2-adaptin, a clathrin adaptor-related protein". J. Virol. 75 (11): 5343–51. doi:10.1128/JVI.75.11.5343-5351.2001. PMC 114939. PMID 11333915.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Janvier K, Craig H, Hitchin D, et al. (2003). "HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes". J. Biol. Chem. 278 (10): 8725–32. doi:10.1074/jbc.M210115200. PMID 12486136.
- Mattera R, Arighi CN, Lodge R, et al. (2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
- Mattera R, Ritter B, Sidhu SS, et al. (2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J. Biol. Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Coleman SH, Van Damme N, Day JR, et al. (2005). "Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes". J. Virol. 79 (4): 2066–78. doi:10.1128/JVI.79.4.2066-2078.2005. PMC 546596. PMID 15681409.
